Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | CDK2 | P24941 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GSR | P00390 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13288997 | 0.92 | ALDH1A1 (0.49) | GSK3BCDK2ALDH1A1GSRRAF1 | |
| SCHEMBL13121210 | 0.90 | GSK3B (0.55) | GSK3BCDK2ALDH1A1GSRMAPK14 | |
| SCHEMBL13288977 | 0.89 | CDK2 (0.47) | GSK3BCDK2ALDH1A1GAAHPGD | |
| SCHEMBL13289501 | 0.89 | ALDH1A1 (0.47) | GSK3BCDK2ALDH1A1GSRBRAF | |
| SCHEMBL13289069 | 0.87 | ALDH1A1 (0.44) | GSK3BCDK2ALDH1A1KMT2A | |
| SCHEMBL14546013 | 0.87 | GSK3B (0.47) | GSK3BCDK2ALDH1A1CYP3A4KMT2A | |
| SCHEMBL13289385 | 0.87 | GSK3B (0.47) | GSK3BCDK2ALDH1A1CYP3A4MEN1 | |
| SCHEMBL13121065 | 0.86 | GSK3B (0.55) | GSK3BCDK2ALDH1A1GSRMAPK14 | |
| SCHEMBL13121142 | 0.86 | GSK3B (0.55) | GSK3BCDK2ALDH1A1GSRMAPK14 | |
| SCHEMBL13289355 | 0.86 | GSK3B (0.43) | GSK3BCDK2ALDH1A1GAAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |