Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 4/20 | 0.47 |
| ▸ | GSK3B | P49841 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.40 |
| ▸ | GNRHR | P30968 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289447 | 0.91 | GSK3B (0.46) | CDK2GSK3BALDH1A1MEN1KMT2A | |
| SCHEMBL13120635 | 0.91 | CDK2 (0.59) | CDK2GSK3BALDH1A1MAPTCYP19A1 | |
| SCHEMBL12954278 | 0.91 | CDK2 (0.52) | CDK2GSK3BALDH1A1MAPTMEN1 | |
| SCHEMBL13288958 | 0.90 | GSK3B (0.46) | CDK2GSK3BALDH1A1MEN1KMT2A | |
| SCHEMBL13289431 | 0.90 | CDK2 (0.49) | CDK2GSK3BMEN1KMT2ACYP19A1 | |
| SCHEMBL13289274 | 0.89 | GSK3B (0.46) | CDK2GSK3BALDH1A1MEN1KMT2A | |
| SCHEMBL13288964 | 0.89 | ALDH1A1 (0.48) | CDK2GSK3BALDH1A1MEN1KMT2A | |
| SCHEMBL13120682 | 0.87 | CDK2 (0.62) | CDK2GSK3BALDH1A1MAPTMEN1 | |
| SCHEMBL13289432 | 0.86 | CDK2 (0.47) | CDK2GSK3BCYP19A1NAMPT | |
| SCHEMBL13288973 | 0.86 | CDK2 (0.48) | CDK2GSK3BALDH1A1MAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2194058-A1 | Pyrazolopyrimidines suitable for the treatment of cancer diseases | SCHERING CORPORATION (US) | 2010-06-09 | — | — | EP | disclosed |