Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 7/20 | 0.76 |
| ▸ | MAPT | P10636 | 5/20 | 0.76 |
| ▸ | PTGES | O14684 | 4/20 | 0.76 |
| ▸ | BACE1 | P56817 | 3/20 | 0.76 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.76 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.76 |
| ▸ | TSHR | P16473 | 2/20 | 0.76 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.76 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.76 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.76 |
| ▸ | MAOA | P21397 | 2/20 | 0.76 |
| ▸ | MAOB | P27338 | 2/20 | 0.76 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.76 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.76 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.76 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1378809 | 0.95 | APP (0.80) | APPMAPTPTGESBACE1NFKB1 | |
| SCHEMBL25771880 | 0.93 | APP (0.69) | APPMAPTPTGESBACE1NFKB1 | |
| SCHEMBL2754851 | 0.92 | NFE2L2 (0.78) | APPMAPTPTGESBACE1NFKB1 | |
| SCHEMBL14141573 | 0.90 | APP (0.76) | APPMAPTPTGESBACE1NFKB1 | |
| SCHEMBL14141572 | 0.90 | APP (0.76) | APPMAPTPTGESBACE1NFKB1 | |
| SCHEMBL30663618 | 0.89 | APP (0.86) | APPMAPTPTGESBACE1NFKB1 | |
| SCHEMBL12253288 | 0.88 | APP (0.91) | APPMAPTPTGESBACE1NFKB1 | |
| SCHEMBL13288495 | 0.88 | APP (0.72) | APPMAPTPTGESBACE1NFKB1 | |
| Curcumin SCHEMBL2804734 | 0.87 | APP (1.00) | APPMAPTPTGESBACE1NFKB1 | |
| Curcumin SCHEMBL17629819 | 0.87 | APP (1.00) | APPMAPTPTGESBACE1NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737183-B2 | β-amyloid and neurofibrillary tangle imaging agents | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-06-15 | — | — | US | disclosed |
| US-20090004107-A1 | BETA-AMYLOID AND NEUROFIBRILLARY TANGLE IMAGING AGENTS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090004107-A1 | BETA-AMYLOID AND NEUROFIBRILLARY TANGLE IMAGING AGENTS | APP, PSEN1, PSEN2 | APP 1/4885MAPT 4/4885PTGES 1434/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.