Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 10/20 | 1.00 |
| ▸ | MAPT | P10636 | 9/20 | 1.00 |
| ▸ | BACE1 | P56817 | 5/20 | 1.00 |
| ▸ | MMP9 | P14780 | 4/20 | 1.00 |
| ▸ | NFKB1 | P19838 | 3/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 1.00 |
| ▸ | TSHR | P16473 | 2/20 | 1.00 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 2/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 2/20 | 1.00 |
| ▸ | MAOA | P21397 | 2/20 | 1.00 |
| ▸ | MAOB | P27338 | 2/20 | 1.00 |
| ▸ | HDAC3 | O15379 | 2/20 | 1.00 |
| ▸ | HDAC1 | Q13547 | 2/20 | 1.00 |
| ▸ | HDAC2 | Q92769 | 2/20 | 1.00 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 1.00 |
| ▸ | ALOX5 | P09917 | 2/20 | 1.00 |
| ▸ | STAT3 | P40763 | 2/20 | 1.00 |
| ▸ | NFKB2 | Q00653 | 2/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Curcumin SCHEMBL29876635 | 1.00 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL29360171 | 1.00 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL17629819 | 1.00 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL250984 | 1.00 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL6901740 | 1.00 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL29358937 | 1.00 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL17629818 | 1.00 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL8336603 | 1.00 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL8440 | 1.00 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 | |
| Curcumin SCHEMBL29355906 | 1.00 | APP (1.00) | APPMAPTBACE1MMP9NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9447023-B2 | Curcumin and tetrahydrocurcumin derivatives | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2016-09-20 | — | — | US | disclosed |
| US-9447023-B2 | Curcumin and tetrahydrocurcumin derivatives | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2016-09-20 | — | — | US | disclosed |
| EP-2076129-B1 | NOVEL CURCUMIN DIMER | UNIV CITY NEW YORK RES FOUND (US) | 2016-05-04 | — | — | EP | disclosed |
| EP-2813145-A1 | Novel curcumin and tetrahydrocurcumin derivatives | Research Foundation Of The City University Of New York (US) | 2014-12-17 | — | — | EP | disclosed |
| EP-2813145-A1 | Novel curcumin and tetrahydrocurcumin derivatives | Research Foundation Of The City University Of New York (US) | 2014-12-17 | — | — | EP | disclosed |
| US-20130296527-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2013-11-07 | — | — | US | disclosed |
| US-20130296527-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2013-11-07 | — | — | US | disclosed |
| US-8487139-B2 | Curcumin and tetrahydrocurcumin derivatives | THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2013-07-16 | — | — | US | disclosed |
| US-8487139-B2 | Curcumin and tetrahydrocurcumin derivatives | THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2013-07-16 | — | — | US | disclosed |
| US-8487139-B2 | Curcumin and tetrahydrocurcumin derivatives | THE RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK | 2013-07-16 | — | — | US | disclosed |
| US-20100240905-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240905-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2010-09-23 | — | — | US | disclosed |
| US-20100240905-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | RESEARCH FOUNDATION OF CITY UNIVERSITY OF NEW YORK (US) | 2010-09-23 | — | — | US | disclosed |
| EP-2076129-A2 | NOVEL CURCUMIN AND TETRAHYDROCURCUMIN DERIVATIVES | The Research Foundation Of the City university of New York (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008045534-A2 | NOVEL CURCUMIN AND TETRAHYDROCURCUMIN DERIVATIVES | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2008-04-17 | — | — | WO | disclosed |
| WO-2008045534-A2 | NOVEL CURCUMIN AND TETRAHYDROCURCUMIN DERIVATIVES | RESEARCH FOUNDATION OF THE CITY UNIVERSITY OF NEW YORK (US) | 2008-04-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100240905-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | BHMT2, HMOX1, DEPTOR | APP 694/4885MAPT 735/4885BACE1 1739/4885 |
| US-20130296527-A1 | Novel Curcumin and Tetrahydrocurcumin Derivatives | BHMT2, HMOX1, DEPTOR | APP 694/4885MAPT 735/4885BACE1 1739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.