Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 8/20 | 0.43 |
| ▸ | CTSS | P25774 | 2/20 | 0.40 |
| ▸ | TLR2 | O60603 | 1/20 | 0.40 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.40 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.40 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.40 |
| ▸ | GRB2 | P62993 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13296602 | 0.94 | PTPN1 (0.43) | PTPN1TLR2TLR1PSMB8PSMB9 | |
| SCHEMBL13296538 | 0.92 | TLR2 (0.42) | PTPN1CTSSTLR2TLR1CTSL | |
| SCHEMBL13296611 | 0.86 | TLR2 (0.42) | PTPN1TLR2TLR1PSMB8PSMB9 | |
| SCHEMBL13296537 | 0.85 | TLR2 (0.42) | TLR2TLR1KMT2A | |
| SCHEMBL13315051 | 0.85 | TLR2 (0.42) | TLR2TLR1KMT2A | |
| SCHEMBL13315113 | 0.84 | PTPN1 (0.43) | PTPN1CTSSCTSLCTSBCTSK | |
| SCHEMBL13296547 | 0.83 | PTPN1 (0.42) | PTPN1CTSSCTSLCTSBCTSK | |
| SCHEMBL30545031 | 0.81 | MDM2 (0.52) | PTPN1TLR2TLR1KMT2A | |
| SCHEMBL13296561 | 0.81 | PTPN1 (0.43) | PTPN1TLR2TLR1GRB2KMT2A | |
| SCHEMBL12340097 | 0.81 | KMT2A (0.48) | PTPN1CTSSTLR2TLR1CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737293-B2 | Amide forming chemical ligation | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-06-15 | — | — | US | disclosed |
| US-20090069536-A1 | Amide Forming Chemical Ligation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2009-03-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069536-A1 | Amide Forming Chemical Ligation | CPS1, GLUL, PCCA | PTPN1 4540/4885CTSS 2188/4885TLR2 4580/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.