Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.51 |
| ▸ | PRKD3 | O94806 | 3/20 | 0.51 |
| ▸ | PAK4 | O96013 | 3/20 | 0.51 |
| ▸ | PRKACA | P17612 | 3/20 | 0.51 |
| ▸ | LTK | P29376 | 3/20 | 0.51 |
| ▸ | GRK5 | P34947 | 3/20 | 0.51 |
| ▸ | CLK2 | P49760 | 3/20 | 0.51 |
| ▸ | CDK7 | P50613 | 3/20 | 0.51 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.51 |
| ▸ | PRKX | P51817 | 3/20 | 0.51 |
| ▸ | PRKCQ | Q04759 | 3/20 | 0.51 |
| ▸ | MST1R | Q04912 | 3/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.51 |
| ▸ | CAMK2A | Q9UQM7 | 3/20 | 0.51 |
| ▸ | DYRK1B | Q9Y463 | 3/20 | 0.51 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1329895 | 0.87 | NUDT1 (0.48) | JAK2PRKD3PAK4PRKACALTK | |
| SCHEMBL1330027 | 0.87 | NUDT1 (0.62) | JAK2PRKD3PAK4PRKACALTK | |
| SCHEMBL1330205 | 0.82 | JAK2 (0.43) | JAK2PRKD3PAK4PRKACALTK | |
| SCHEMBL1328408 | 0.79 | ROCK1 (0.46) | JAK2PRKD3PAK4PRKACALTK | |
| SCHEMBL27829004 | 0.79 | NUDT1 (0.43) | JAK2PRKD3PAK4PRKACALTK | |
| SCHEMBL1327987 | 0.78 | PTK2 (0.43) | JAK2PRKD3PAK4PRKACALTK | |
| SCHEMBL1328071 | 0.78 | PRKCI (0.46) | JAK2PRKD3PAK4PRKACALTK | |
| SCHEMBL1328116 | 0.77 | NUDT1 (0.44) | JAK2PRKD3PAK4PRKACALTK | |
| SCHEMBL10125427 | 0.77 | NUDT1 (0.75) | JAK2PRKD3PAK4PRKACALTK | |
| SCHEMBL27829003 | 0.77 | ROCK1 (0.44) | JAK2PRKD3PAK4PRKACALTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-11-17 | — | — | US | claimed |
| EP-2231282-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | Merck Patent GmbH (DE) | 2010-09-29 | — | — | EP | claimed |
| WO-2009094123-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK SERONO S.A. (CH) | 2009-07-30 | — | — | WO | claimed |
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MAP3K19, MAP3K20, MAP3K1 | JAK2 196/4885PRKD3 105/4885PAK4 171/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.