Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 3/20 | 0.40 |
| ▸ | MELK | Q14680 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 4/20 | 0.40 |
| ▸ | PRKACA | P17612 | 4/20 | 0.40 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.40 |
| ▸ | CSNK1A1 | P48729 | 3/20 | 0.40 |
| ▸ | CDK9 | P50750 | 3/20 | 0.40 |
| ▸ | GSK3A | P49840 | 2/20 | 0.40 |
| ▸ | GSK3B | P49841 | 2/20 | 0.40 |
| ▸ | TAOK1 | Q7L7X3 | 2/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1328470 | 0.84 | NUDT1 (0.40) | JAK2JAK1TYK2NUDT1JAK3 | |
| SCHEMBL27829003 | 0.83 | ROCK1 (0.44) | JAK2JAK1TYK2NUDT1JAK3 | |
| SCHEMBL1329657 | 0.82 | JAK2 (0.51) | JAK2JAK1TYK2NUDT1JAK3 | |
| SCHEMBL27829008 | 0.81 | JAK3 (0.38) | NUDT1JAK3MELKROCK2ROCK1 | |
| SCHEMBL1328582 | 0.80 | KDM4E (0.55) | JAK3MELKMEN1KMT2ACIT | |
| SCHEMBL1328187 | 0.79 | JAK3 (0.53) | JAK2JAK1TYK2JAK3MELK | |
| SCHEMBL2098077 | 0.78 | NUDT1 (0.60) | JAK2NUDT1JAK3ROCK1PRKD3 | |
| SCHEMBL1329895 | 0.78 | NUDT1 (0.48) | JAK2JAK1TYK2NUDT1JAK3 | |
| SCHEMBL1328408 | 0.77 | ROCK1 (0.46) | JAK2JAK1TYK2NUDT1JAK3 | |
| SCHEMBL1330027 | 0.77 | NUDT1 (0.62) | JAK2JAK1TYK2NUDT1JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-11-17 | — | — | US | claimed |
| CN-101918079-A | Protein kinase inhibitors and use thereof | MERCK SERONO SA | 2010-12-15 | — | — | CN | claimed |
| EP-2231282-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | Merck Patent GmbH (DE) | 2010-09-29 | — | — | EP | claimed |
| WO-2009094123-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK SERONO S.A. (CH) | 2009-07-30 | — | — | WO | claimed |
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MERCK PATENT GMBH (DE) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110282056-A1 | PROTEIN KINASE INHIBITORS AND USE THEREOF | MAP3K19, MAP3K20, MAP3K1 | JAK2 196/4885JAK1 193/4885TYK2 382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.