Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | THRB | P10828 | 1/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.63 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.63 |
| ▸ | THPO | P40225 | 1/20 | 0.63 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | BLM | P54132 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | BMP1 | P13497 | 2/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MMP1 | P03956 | 5/20 | 0.35 |
| ▸ | MMP9 | P14780 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 2/20 | 0.34 |
| ▸ | MMP8 | P22894 | 2/20 | 0.34 |
| ▸ | MMP3 | P08254 | 2/20 | 0.34 |
| ▸ | FNTA | P49354 | 1/20 | 0.33 |
| ▸ | FNTB | P49356 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12632549 | 1.00 | KDM4E (0.63) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL10045860 | 1.00 | KDM4E (0.63) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL20328839 | 0.85 | KDM4E (0.52) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL4990551 | 0.84 | BMP1 (0.45) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL17623527 | 0.83 | KDM4E (0.48) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL4704123 | 0.83 | BMP1 (0.47) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL4988312 | 0.83 | BMP1 (0.44) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL12354387 | 0.81 | KDM4E (0.61) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL928644 | 0.81 | KDM4E (0.61) | KDM4EMAPTTHRBALOX15NFKB1 | |
| SCHEMBL27447128 | 0.81 | KDM4E (0.61) | KDM4EMAPTTHRBALOX15NFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170135970-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) IN THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | GOLDSTEIN GLENN A (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170135970-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) IN THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | GOLDSTEIN GLENN A (US) | 2017-05-18 | — | — | US | disclosed |
| US-20160206576-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) IN THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | GOLDSTEIN GLENN A (US) | 2016-07-21 | — | — | US | disclosed |
| US-20160206576-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) IN THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | GOLDSTEIN GLENN A (US) | 2016-07-21 | — | — | US | disclosed |
| US-9216162-B2 | N-acetylcysteine amide (NAC amide) in the treatment of diseases and conditions associated with oxidative stress | GOLDSTEIN GLENN A (US) | 2015-12-22 | — | — | US | disclosed |
| US-9216162-B2 | N-acetylcysteine amide (NAC amide) in the treatment of diseases and conditions associated with oxidative stress | GOLDSTEIN GLENN A (US) | 2015-12-22 | — | — | US | disclosed |
| US-20150164830-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) IN THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | SENTIENT LIFESCIENCES INC (US) | 2015-06-18 | — | — | US | disclosed |
| US-20150164830-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) IN THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | SENTIENT LIFESCIENCES INC (US) | 2015-06-18 | — | — | US | disclosed |
| US-8993627-B2 | N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress | SENTIENT LIFESCIENCES, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-8993627-B2 | N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress | SENTIENT LIFESCIENCES, INC. (US) | 2015-03-31 | — | — | US | disclosed |
| US-20140187640-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | SENTIENT LIFESCIENCES, INC. | 2014-07-03 | — | — | US | disclosed |
| US-20140187640-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | SENTIENT LIFESCIENCES, INC. | 2014-07-03 | — | — | US | disclosed |
| US-8354449-B2 | N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress | SENTIENT LIFESCIENCES, INC. | 2013-01-15 | — | — | US | disclosed |
| US-8354449-B2 | N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress | SENTIENT LIFESCIENCES, INC. | 2013-01-15 | — | — | US | disclosed |
| US-20100137441-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | SENTIENT LIFESCIENCES, INC. | 2010-06-03 | — | — | US | disclosed |
| US-20100137441-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | SENTIENT LIFESCIENCES, INC. | 2010-06-03 | — | — | US | disclosed |
| US-20100120920-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | SENTIENT LIFESCIENCES, INC. | 2010-05-13 | — | — | US | disclosed |
| US-20100120920-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | SENTIENT LIFESCIENCES, INC. | 2010-05-13 | — | — | US | disclosed |
| US-20090234011-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | DAVID PHARMACEUTICALS | 2009-09-17 | — | — | US | disclosed |
| US-20090234011-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | DAVID PHARMACEUTICALS | 2009-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140187640-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | GCLC, NAT1, HHAT | KDM4E 4862/4885MAPT 1119/4885THRB 1897/4885 |
| US-20160206576-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) IN THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | GCLC, NAT1, HHAT | KDM4E 4864/4885MAPT 1059/4885THRB 1957/4885 |
| US-20100120920-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | GCLC, NAT1, HHAT | KDM4E 4862/4885MAPT 1119/4885THRB 1897/4885 |
| US-20170135970-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) IN THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | GCLC, NAT1, HHAT | KDM4E 4864/4885MAPT 1059/4885THRB 1957/4885 |
| US-20100137441-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | GCLC, NAT1, HHAT | KDM4E 4862/4885MAPT 1119/4885THRB 1897/4885 |
| US-20150164830-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) IN THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | GCLC, NAT1, HHAT | KDM4E 4864/4885MAPT 1059/4885THRB 1957/4885 |
| US-20090234011-A1 | N-ACETYLCYSTEINE AMIDE (NAC AMIDE) FOR THE TREATMENT OF DISEASES AND CONDITIONS ASSOCIATED WITH OXIDATIVE STRESS | GCLC, NAT1, HHAT | KDM4E 4862/4885MAPT 1119/4885THRB 1897/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.