SCHEMBL13299873

SCHEMBL13299873

CC(C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CCCCC(C)(C)NC(=O)c1ccc(O)cn1)C(C)C)C(=O)c1nnc(C(C)(C)C)o1

nearest known ligand 0.43

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ELANE P08246 20/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13299874 0.94 ELANE (0.42) ELANE
SCHEMBL13299857 0.94 ELANE (0.38) ELANE
SCHEMBL13299852 0.92 ELANE (0.43) ELANE
SCHEMBL13814744 0.90 ELANE (0.46) ELANE
SCHEMBL13299705 0.90 ELANE (0.42) ELANE
SCHEMBL13299855 0.90 ELANE (0.46) ELANE
SCHEMBL13299735 0.89 ELANE (0.42) ELANE
SCHEMBL13814747 0.89 ELANE (0.42) ELANE
SCHEMBL13299704 0.88 ELANE (0.43) ELANE
SCHEMBL13814754 0.88 ELANE (0.41) ELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010065461-A1 TRI-PEPTIDE INHIBITORS OF SERINE ELASTASES ACCUTHERA, INC. (US) 2010-06-10 WO disclosed
US-20090156509-A1 Tri-peptide Inhibitors of Serine Elastases ACCUTHERA, INC. (US) 2009-06-18 US disclosed
US-20090156509-A1 Tri-peptide Inhibitors of Serine Elastases ACCUTHERA, INC. (US) 2009-06-18 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090156509-A1 Tri-peptide Inhibitors of Serine Elastases SCTR, CTRC, SERPINB1 ELANE 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.