Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | HPRT1 | P00492 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.41 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13207448 | 0.92 | ALDH1A1 (0.41) | HSD17B10ALDH1A1CYP2A6TSHRTDP1 | |
| SCHEMBL30367845 | 0.79 | HSD17B10 (0.50) | HSD17B10ALDH1A1CYP2A6TSHRTDP1 | |
| SCHEMBL30066585 | 0.79 | CYP2A6 (0.50) | HSD17B10ALDH1A1CYP2A6TSHRTDP1 | |
| SCHEMBL6267184 | 0.79 | CYP2A6 (0.50) | HSD17B10ALDH1A1CYP2A6TSHRTDP1 | |
| SCHEMBL8050013 | 0.79 | HSD17B10 (0.50) | HSD17B10ALDH1A1CYP2A6TSHRTDP1 | |
| SCHEMBL15263192 | 0.77 | ALDH1A1 (0.48) | HSD17B10ALDH1A1CYP2A6TSHRTDP1 | |
| SCHEMBL5691676 | 0.77 | ALDH1A1 (0.48) | HSD17B10ALDH1A1CYP2A6TSHRTDP1 | |
| SCHEMBL14392713 | 0.77 | ALDH1A1 (0.48) | HSD17B10ALDH1A1CYP2A6TSHRTDP1 | |
| SCHEMBL30066580 | 0.77 | ALDH1A1 (0.48) | HSD17B10ALDH1A1CYP2A6TSHRTDP1 | |
| SCHEMBL12807315 | 0.77 | HSD17B10 (0.48) | HSD17B10ALDH1A1CYP2A6TSHRTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9718823-B2 | 2, 6-Di-nitrogen-containing substituted purine derivative, and preparation method, pharmaceutical composition and use thereof | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2017-08-01 | — | — | US | disclosed |
| US-20160207924-A1 | 2, 6-Di-Nitrogen-Containing Substituted Purine Derivative, And Preparation Method, Pharmaceutical Composition And Use Thereof | ZHEJIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2016-07-21 | — | — | US | disclosed |
| US-8580763-B2 | 2, 6-dinitrogen-containing substituted purine derivatives, the preparation and uses thereof | ZHANGGUI WU (CN) | 2013-11-12 | — | — | US | disclosed |
| US-20100144663-A1 | 2, 6-Dinitrogen-Containing Substituted Purine Derivatives, The Preparation And Uses Thereof | ZHE JIANG MEDICINE CO., LTD. XINCHANG PHARMACEUTICAL FACTORY (CN) | 2010-06-10 | — | — | US | disclosed |
| EP-1529768-B1 | Process for the preparation of TCD-alcohol DM | OXEA DEUTSCHLAND GMBH (DE) | 2007-10-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160207924-A1 | 2, 6-Di-Nitrogen-Containing Substituted Purine Derivative, And Preparation Method, Pharmaceutical Composition And Use Thereof | NUDT1, PNP, SLC29A2 | HSD17B10 3968/4885ALDH1A1 693/4885CYP2A6 323/4885 |
| US-20100144663-A1 | 2, 6-Dinitrogen-Containing Substituted Purine Derivatives, The Preparation And Uses Thereof | PNP, NUDT1, DPYD | HSD17B10 3467/4885ALDH1A1 254/4885CYP2A6 153/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.