Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | IGF1R | P08069 | 1/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.38 |
| ▸ | PRKACA | P17612 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | LTK | P29376 | 1/20 | 0.38 |
| ▸ | GRK5 | P34947 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27944249 | 0.84 | MAPT (0.46) | MAPTIKBKBCHUKDAPK3JAK2 | |
| SCHEMBL27944237 | 0.84 | MAPT (0.42) | MAPTIKBKBCHUKDAPK3JAK2 | |
| SCHEMBL27954146 | 0.84 | MAPT (0.46) | MAPTIKBKBCHUKDAPK3JAK2 | |
| SCHEMBL27944264 | 0.81 | MAPT (0.40) | MAPTIKBKBCHUKDAPK3JAK2 | |
| SCHEMBL27944265 | 0.81 | MAPT (0.40) | MAPTIKBKBCHUKDAPK3JAK2 | |
| SCHEMBL27944226 | 0.76 | MAPT (0.42) | MAPTIKBKBCHUKDAPK3JAK2 | |
| SCHEMBL28809811 | 0.76 | MAPT (0.42) | MAPTIKBKBCHUKDAPK3JAK2 | |
| SCHEMBL27954121 | 0.73 | MAPT (0.43) | MAPTIKBKBCHUKDAPK3JAK2 | |
| SCHEMBL27954120 | 0.73 | MAPT (0.43) | MAPTIKBKBCHUKDAPK3JAK2 | |
| SCHEMBL7217545 | 0.72 | PARP1 (0.40) | JAK2PRKD3MAP4K4PAK4IGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11116774-B2 | Modulators of toll-like receptors for the treatment of HIV | GILEAD SCIENCES, INC. (US) | 2021-09-14 | — | — | US | disclosed |
| US-20180085370-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2018-03-29 | — | — | US | disclosed |
| US-20170065592-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2017-03-09 | — | — | US | disclosed |
| US-20170065592-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2017-03-09 | — | — | US | disclosed |
| US-9573952-B2 | Methods of preparing toll-like receptor modulators | GILEAD SCIENCES, INC. (US) | 2017-02-21 | — | — | US | disclosed |
| US-9452166-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2016-09-27 | — | — | US | disclosed |
| US-20160075707-A1 | METHODS OF PREPARING TOLL-LIKE RECEPTOR MODULATORS | GILEAD SCIENCES, INC. | 2016-03-17 | — | — | US | disclosed |
| US-20160015713-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2016-01-21 | — | — | US | disclosed |
| US-20160008374-A1 | MODULATORS OF TOLL-LIKE RECEPTORS FOR THE TREATMENT OF HIV | GILEAD SCIENCES, INC. | 2016-01-14 | — | — | US | disclosed |
| US-9127006-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2015-09-08 | — | — | US | disclosed |
| US-20140316132-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2014-10-23 | — | — | US | disclosed |
| US-8809527-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20140081022-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. | 2014-03-20 | — | — | US | disclosed |
| US-8629142-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2014-01-14 | — | — | US | disclosed |
| US-20130071354-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2013-03-21 | — | — | US | disclosed |
| US-8367670-B2 | Modulators of toll-like receptors | GILEAD SCIENCES, INC. (US) | 2013-02-05 | — | — | US | disclosed |
| US-20100143301-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | GILEAD SCIENCES, INC. (US) | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160075707-A1 | METHODS OF PREPARING TOLL-LIKE RECEPTOR MODULATORS | TLR3, TLR4, TLR6 | MAPT 4719/4885IKBKB 346/4885CHUK 581/4885 |
| US-20180085370-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | TLR3, TLR2, TLR6 | MAPT 4410/4885IKBKB 148/4885CHUK 648/4885 |
| US-20160008374-A1 | MODULATORS OF TOLL-LIKE RECEPTORS FOR THE TREATMENT OF HIV | TLR7, TLR3, TLR6 | MAPT 3071/4885IKBKB 189/4885CHUK 614/4885 |
| US-20100143301-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | TLR3, TLR2, TLR6 | MAPT 4410/4885IKBKB 148/4885CHUK 648/4885 |
| US-11116774-B2 | Modulators of toll-like receptors for the treatment of HIV | TLR7, TLR3, TLR6 | MAPT 3071/4885IKBKB 189/4885CHUK 614/4885 |
| US-20140316132-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | TLR3, TLR2, TLR6 | MAPT 4410/4885IKBKB 148/4885CHUK 648/4885 |
| US-20140081022-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | TLR3, TLR2, TLR6 | MAPT 4410/4885IKBKB 148/4885CHUK 648/4885 |
| US-20160015713-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | TLR3, TLR2, TLR6 | MAPT 4410/4885IKBKB 148/4885CHUK 648/4885 |
| US-20170065592-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | TLR3, TLR2, TLR6 | MAPT 4410/4885IKBKB 148/4885CHUK 648/4885 |
| US-20130071354-A1 | MODULATORS OF TOLL-LIKE RECEPTORS | TLR3, TLR2, TLR6 | MAPT 4410/4885IKBKB 148/4885CHUK 648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.