SCHEMBL13302007

SCHEMBL13302007

N#CC(C#N)=C1C(=O)c2ccccc2-c2ccc(C(F)(F)F)cc21

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 4/20 0.42
ALDH1A1 P00352 3/20 0.42
PKM P14618 2/20 0.42
GAA P10253 1/20 0.42
NPC1 O15118 2/20 0.41
CASP3 P42574 2/20 0.41
RAB9A P51151 2/20 0.41
SENP8 Q96LD8 2/20 0.41
SENP7 Q9BQF6 2/20 0.41
SENP6 Q9GZR1 2/20 0.41
PLA2G1B P04054 2/20 0.41
ATG4B Q9Y4P1 2/20 0.41
NFKB1 P19838 1/20 0.41
NFKB2 Q00653 1/20 0.41
RELA Q04206 1/20 0.41
L3MBTL1 Q9Y468 1/20 0.41
DHODH Q02127 1/20 0.39
GPR3 P46089 1/20 0.39
MAOB P27338 2/20 0.38
PTGDR2 Q9Y5Y4 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13302009 0.93 MAPT (0.45) MAPTALDH1A1PKMGAANPC1
SCHEMBL11585999 0.88 ALDH1A1 (0.43) MAPTALDH1A1PKMGAAGPR3
SCHEMBL13694208 0.85 MAPT (0.40) MAPTALDH1A1PKMGAAMAOB
SCHEMBL13292068 0.83 NPC1 (0.36) MAPTALDH1A1NPC1CASP3RAB9A
SCHEMBL15779897 0.82 MAPT (0.45) MAPTALDH1A1PKMGAADHODH
SCHEMBL23443607 0.80 ALDH1A1 (0.37) MAPTALDH1A1PKMGAADHODH
SCHEMBL13302006 0.79 TDP2 (0.55) MAPTALDH1A1PKMGAANPC1
SCHEMBL31674878 0.78 NPC1 (0.63) MAPTALDH1A1NPC1CASP3RAB9A
SCHEMBL7791837 0.78 NPC1 (0.63) MAPTALDH1A1NPC1CASP3RAB9A
SCHEMBL28626995 0.78 NPC1 (0.58) MAPTALDH1A1NPC1CASP3RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7745083-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2010-06-29 US disclosed
US-20090297218-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2009-12-03 US disclosed
US-7592113-B2 Electrophotographic photosensitive member, process cartridge, and electrophotographic apparatus CANON KABUSHIKI KAISHA (JP) 2009-09-22 US disclosed
US-20080233499-A1 ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, PROCESS CARTRIDGE, AND ELECTROPHOTOGRAPHIC APPARATUS CANON KABUSHIKI KAISHA (JP) 2008-09-25 US disclosed
US-7396622-B2 Having a charge generation layer containing a phenanthrene compound, a phenanthroline compound or an acenaphthene compound that has two oxo-, phenylimino- or dicyanovinylene groups that may be the same or different; charge-generating material is preferably hydroxygallium phthalocyanine. CANON KABUSHIKI KAISHA (JP) 2008-07-08 US disclosed