Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Strychnine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 15/20 | 0.87 |
| ▸ | GLRB | P48167 | 15/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.87 |
| ▸ | MEN1 | O00255 | 2/20 | 0.87 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.87 |
| ▸ | TAS2R10 | Q9NYW0 | 2/20 | 0.87 |
| ▸ | SCN1A | P35498 | 1/20 | 0.87 |
| ▸ | TAS2R46 | P59540 | 1/20 | 0.87 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.87 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.87 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Strychnine SCHEMBL22472359 | 0.93 | GLRA1 (0.90) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL14047653 | 0.93 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL21985190 | 0.93 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL14029424 | 0.93 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL29352583 | 0.93 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL29362678 | 0.93 | GLRA1 (1.00) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL25300604 | 0.92 | GLRA1 (0.98) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL31047368 | 0.92 | GLRA1 (0.98) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL8387651 | 0.92 | GLRA1 (0.87) | GLRA1GLRBCYP3A4MEN1KMT2A | |
| Strychnine SCHEMBL29729432 | 0.91 | GLRA1 (0.91) | GLRA1GLRBCYP3A4MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8273542-B2 | Human T2R receptors for acetaminophen, ranitidine, strychnine and denatonium and related assays for identifying human bitter taste modulators | SENOMYX, INC. (US) | 2012-09-25 | — | — | US | disclosed |
| US-20110281749-A1 | HUMAN T2R RECEPTORS FOR ACETAMINOPHEN, RANITIDINE, STRYCHNINE AND DENATONIUM AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS | SENOMYX, INC. | 2011-11-17 | — | — | US | disclosed |
| US-7915003-B2 | Human T2R receptors for ranitidine, strychnine and denatonium and related assays for identifying human bitter taste modulators | SENOMYX, INC. (US) | 2011-03-29 | — | — | US | disclosed |
| US-20090087866-A1 | HUMAN T2R RECEPTORS FOR RANITIDINE, STRYCHNINE AND DENATONIUM AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS | FIRMENICH INCORPORATED | 2009-04-02 | — | — | US | disclosed |
| US-7407765-B2 | Human T2R receptors for acetaminophen ranitidine, strychnine and denatomium and related assays for identifying human bitter taste modulators | SENOMYX, INC. (US) | 2008-08-05 | — | — | US | disclosed |
| EP-1851548-A2 | PHUMAN T2R RECEPTORS FOR ACETAMINOPHEN, RANITIDINE, STRYCHNINE AND DENATONIUM AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS | Senomyx, Inc. (US) | 2007-11-07 | — | — | EP | disclosed |
| US-20060199227-A1 | pHuman T2R receptors for acetaminophen ranitidine, strychnine and denatomium and related assays for identifying human bitter taste modulators | FIRMENICH INCORPORATED | 2006-09-07 | — | — | US | disclosed |
| WO-2006086150-A2 | PHUMAN T2R RECEPTORS FOR ACETAMINOPHEN, RANITIDINE, STRYCHNINE AND DENATONIUM AND RELATED ASSAYS FOR IDENTIFYING HUMAN BITTER TASTE MODULATORS | SENOMYX, INC. (US) | 2006-08-17 | — | — | WO | disclosed |