Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Strychnine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA1 | P23415 | 15/20 | 0.90 |
| ▸ | GLRB | P48167 | 15/20 | 0.90 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.90 |
| ▸ | TAS2R10 | Q9NYW0 | 2/20 | 0.90 |
| ▸ | MEN1 | O00255 | 2/20 | 0.90 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.90 |
| ▸ | SCN1A | P35498 | 1/20 | 0.90 |
| ▸ | TAS2R46 | P59540 | 1/20 | 0.90 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.90 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.90 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Strychnine SCHEMBL14029424 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4TAS2R10MEN1 | |
| Strychnine SCHEMBL14117483 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4TAS2R10MEN1 | |
| Strychnine SCHEMBL21985190 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4TAS2R10MEN1 | |
| Strychnine SCHEMBL14047653 | 0.95 | GLRA1 (1.00) | GLRA1GLRBCYP3A4TAS2R10MEN1 | |
| Strychnine SCHEMBL15475787 | 0.94 | GLRA1 (0.95) | GLRA1GLRBCYP3A4TAS2R10MEN1 | |
| Strychnine SCHEMBL25300604 | 0.94 | GLRA1 (0.98) | GLRA1GLRBCYP3A4TAS2R10MEN1 | |
| Strychnine SCHEMBL31047368 | 0.94 | GLRA1 (0.98) | GLRA1GLRBCYP3A4TAS2R10MEN1 | |
| Strychnine SCHEMBL184168 | 0.94 | GLRA1 (0.98) | GLRA1GLRBCYP3A4TAS2R10MEN1 | |
| Strychnine SCHEMBL8387651 | 0.93 | GLRA1 (0.87) | GLRA1GLRBCYP3A4TAS2R10MEN1 | |
| Strychnine SCHEMBL235087 | 0.92 | GLRA1 (0.91) | GLRA1GLRBCYP3A4TAS2R10MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11883458-B2 | Herb medicine composition for alleviating or treating asthma, and oriental pharmacopuncture solution containing same and injection containing same | KIM SUNG KI (KR) | 2024-01-30 | — | — | US | disclosed |
| US-20220249589-A1 | HERB MEDICINE COMPOSITION FOR ALLEVIATING OR TREATING ASTHMA, AND ORIENTAL PHARMACOPUNCTURE SOLUTION CONTAINING SAME AND INJECTION CONTAINING SAME | KIM SUNG KI (KR) | 2022-08-11 | — | — | US | disclosed |
| CN-108117557-B | Extraction, separation and purification method of strychnine | 北京盈科瑞创新医药股份有限公司 | 2022-05-27 | — | — | CN | disclosed |
| WO-2020197036-A1 | HERB MEDICINE COMPOSITION FOR ALLEVIATING OR TREATING ASTHMA, AND ORIENTAL PHARMACOPUNCTURE SOLUTION CONTAINING SAME AND INJECTION CONTAINING SAME | 김성기 | 2020-10-01 | — | — | WO | disclosed |