Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC3 | Q13507 | 2/20 | 0.49 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 2/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 6/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953255 | 0.90 | CHEK1 (0.48) | TRPC3TRPC7SMN1; SMN2CYP2C19NPC1 | |
| SCHEMBL12953546 | 0.89 | TRPC3 (0.53) | TRPC3TRPC7SMN1; SMN2CYP2C19NPC1 | |
| SCHEMBL13901487 | 0.89 | TRPC3 (0.49) | TRPC3TRPC7SMN1; SMN2CYP2C19NPC1 | |
| SCHEMBL13998619 | 0.84 | GRIN2B (0.52) | TRPC3TRPC7SMN1; SMN2CYP2C19NPC1 | |
| SCHEMBL12954092 | 0.83 | GSK3B (0.49) | TRPC3TRPC7SMN1; SMN2CYP2C19NPC1 | |
| SCHEMBL14547312 | 0.82 | TRPC3 (0.43) | TRPC3TRPC7SMN1; SMN2CYP2C19NPC1 | |
| SCHEMBL13998618 | 0.82 | GSK3B (0.54) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12953650 | 0.82 | GSK3B (0.54) | TRPC3TRPC7SMN1; SMN2NPC1RAB9A | |
| SCHEMBL12953929 | 0.82 | GSK3B (0.71) | CDK2GSK3B | |
| SCHEMBL12953550 | 0.81 | GSK3B (0.52) | TRPC3TRPC7RAB9ACDK2GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7468372-B2 | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-23 | — | — | US | disclosed |
| US-7468372-B2 | Trisubstituted 4-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2008-12-23 | — | — | US | disclosed |