Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK1 | P23458 | 2/20 | 0.41 |
| ▸ | TYK2 | P29597 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 3/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | TRPC3 | Q13507 | 2/20 | 0.39 |
| ▸ | TRPC7 | Q9HCX4 | 2/20 | 0.39 |
| ▸ | BCL9 | O00512 | 1/20 | 0.38 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953762 | 0.91 | GSK3B (0.51) | MAP3K12MAPK1CDK2CHEK1CCNA2 | |
| SCHEMBL13304793 | 0.91 | MAPK1 (0.41) | MAP3K12MAPK1CDK2CHEK1CCNA2 | |
| SCHEMBL13305223 | 0.85 | TRPC3 (0.44) | MAP3K12MAPK1CDK2CHEK1CCNA2 | |
| SCHEMBL12953558 | 0.84 | GSK3B (0.50) | MAPK1CDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL12953266 | 0.80 | GSK3B (0.51) | CDK2CHEK1CCNA2CCNA1JAK2 | |
| SCHEMBL12954179 | 0.80 | GSK3B (0.67) | CDK2GSK3B | |
| SCHEMBL14607246 | 0.78 | GSK3B (0.53) | MAP3K12CDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL14412769 | 0.77 | GSK3B (0.47) | MAPK1CDK2CHEK1CCNA2CCNA1 | |
| SCHEMBL14418651 | 0.76 | GSK3B (0.55) | CDK2CHEK1CCNA2CCNA1GSK3B | |
| SCHEMBL12953255 | 0.76 | CHEK1 (0.48) | CDK2CHEK1CCNA2CCNA1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |