Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 6/20 | 0.50 |
| ▸ | CDK2 | P24941 | 11/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GPR39 | O43194 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.40 |
| ▸ | CDK7 | P50613 | 2/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | CDK8 | P49336 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | CCNH | P51946 | 1/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13289158 | 0.89 | CDK2 (0.63) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL14043231 | 0.83 | GSK3B (0.50) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13305418 | 0.82 | CDK2 (0.63) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL14545984 | 0.82 | CDK2 (0.49) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL14301243 | 0.80 | GSK3B (0.48) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13304831 | 0.79 | CDK2 (0.58) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13305297 | 0.78 | CDK2 (0.77) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13304918 | 0.77 | GSK3B (0.62) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13305400 | 0.77 | CDK2 (0.57) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13304910 | 0.77 | GSK3B (0.60) | GSK3BCDK2MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |