Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 5/20 | 0.50 |
| ▸ | CDK2 | P24941 | 13/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.46 |
| ▸ | GPR39 | O43194 | 1/20 | 0.45 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14301243 | 0.90 | GSK3B (0.48) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13305418 | 0.89 | CDK2 (0.63) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13305293 | 0.83 | GSK3B (0.50) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL14043437 | 0.81 | CDK2 (0.44) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL14301725 | 0.81 | SMO (0.45) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL14545978 | 0.81 | GSK3B (0.47) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL13289158 | 0.80 | CDK2 (0.63) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL14418865 | 0.80 | GSK3B (0.41) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL12954196 | 0.79 | GSK3B (0.50) | GSK3BCDK2MEN1KMT2ANPC1 | |
| SCHEMBL14301598 | 0.79 | GSK3B (0.66) | GSK3BCDK2CCNE1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |