Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.44 |
| ▸ | GSK3B | P49841 | 3/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14545787 | 0.90 | CDK2 (0.45) | CDK2GSK3BCHEK1CCNA2CCNA1 | |
| SCHEMBL12953175 | 0.83 | CDK2 (0.62) | CDK2GSK3BCCNE1 | |
| SCHEMBL12953217 | 0.75 | CDK2 (0.62) | CDK2GSK3BCCNE1 | |
| SCHEMBL13304953 | 0.73 | GSK3B (0.49) | CDK2GSK3BCCNE1ALDH1A1MEN1 | |
| SCHEMBL12953041 | 0.70 | CDK2 (0.69) | CDK2GSK3BCCNE1 | |
| SCHEMBL14043147 | 0.69 | GSK3B (0.46) | CDK2GSK3BCHEK1CCNA2CCNA1 | |
| SCHEMBL12953228 | 0.68 | CDK2 (0.72) | CDK2GSK3BCHEK1CCNA2CCNA1 | |
| SCHEMBL12953362 | 0.68 | CDK2 (0.68) | CDK2GSK3BCCNE1 | |
| SCHEMBL12953028 | 0.68 | CDK2 (0.68) | CDK2GSK3BCCNE1 | |
| SCHEMBL12954112 | 0.67 | CDK2 (0.70) | CDK2GSK3BCHEK1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537116-B1 | PYRAZOLOPYRIMIDINES SUITABLE FOR THE TREATMENT OF CANCER DISEASES | SCHERING CORP (US) | 2010-06-02 | — | — | EP | disclosed |
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |