Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.45 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.42 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | BTK | Q06187 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13305603 | 0.90 | CDK2 (0.44) | CDK2GSK3BCHEK1CCNA2CCNA1 | |
| SCHEMBL12953217 | 0.85 | CDK2 (0.62) | CDK2GSK3BCCNE1 | |
| SCHEMBL13146084 | 0.74 | GSK3B (0.49) | CDK2GSK3BCCNE1SLC2A1KDM4E | |
| SCHEMBL12953175 | 0.73 | CDK2 (0.62) | CDK2GSK3BCCNE1 | |
| SCHEMBL12953041 | 0.71 | CDK2 (0.69) | CDK2GSK3BCCNE1 | |
| SCHEMBL13116791 | 0.70 | CDK2 (0.63) | CDK2GSK3BCCNA2CCNA1CCNE1 | |
| SCHEMBL12953228 | 0.69 | CDK2 (0.72) | CDK2GSK3BCHEK1CCNA2CCNA1 | |
| SCHEMBL12953028 | 0.69 | CDK2 (0.68) | CDK2GSK3BCCNE1 | |
| SCHEMBL17690923 | 0.67 | GSK3B (0.48) | CDK2GSK3BCCNE1MAPK1 | |
| SCHEMBL14043147 | 0.67 | GSK3B (0.46) | CDK2GSK3BCHEK1CCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044449-A2 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2007-04-19 | — | — | WO | disclosed |