Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 3/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12953359 | 0.79 | GSK3B (0.69) | GSK3BKDM4EHPGDNPC1RAB9A | |
| SCHEMBL12953467 | 0.70 | GSK3B (0.58) | GSK3BKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL12953252 | 0.70 | CDK2 (0.64) | GSK3BKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL13305603 | 0.69 | CDK2 (0.44) | GSK3BKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL17690923 | 0.69 | GSK3B (0.48) | GSK3BCDK2CCNE1ADORA2A | |
| SCHEMBL14545787 | 0.67 | CDK2 (0.45) | GSK3BKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL13146697 | 0.67 | GSK3B (0.71) | GSK3BNPC1RAB9AKMT2AMEN1 | |
| SCHEMBL27369472 | 0.66 | GSK3B (0.76) | GSK3BKDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL12954112 | 0.66 | CDK2 (0.70) | GSK3BCDK2CCNE1CHEK1CCNA2 | |
| SCHEMBL27370878 | 0.65 | GSK3B (0.72) | GSK3BNPC1RAB9AKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130570-A1 | NOVEL PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS | SCHERING CORPORATION (US) | 2008-10-30 | — | — | WO | disclosed |