Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.57 |
| ▸ | DDR2 | Q16832 | 4/20 | 0.57 |
| ▸ | KDR | P35968 | 11/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 9/20 | 0.55 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.55 |
| ▸ | KIT | P10721 | 5/20 | 0.55 |
| ▸ | LCK | P06239 | 4/20 | 0.55 |
| ▸ | AURKA | O14965 | 4/20 | 0.55 |
| ▸ | FYN | P06241 | 4/20 | 0.55 |
| ▸ | CSF1R | P07333 | 4/20 | 0.55 |
| ▸ | LYN | P07948 | 4/20 | 0.55 |
| ▸ | FLT1 | P17948 | 4/20 | 0.55 |
| ▸ | BLK | P51451 | 4/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.55 |
| ▸ | FLT3 | P36888 | 4/20 | 0.55 |
| ▸ | NTRK2 | Q16620 | 4/20 | 0.55 |
| ▸ | MET | P08581 | 3/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.55 |
| ▸ | ABL1 | P00519 | 3/20 | 0.55 |
| ▸ | SRC | P12931 | 3/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1331406 | 0.92 | FGFR1 (0.58) | FGFR1DDR2KDRAURKBNTRK1 | |
| SCHEMBL1331637 | 0.90 | KDR (0.64) | FGFR1DDR2KDRAURKBNTRK1 | |
| SCHEMBL1330849 | 0.89 | KDR (0.56) | FGFR1DDR2KDRAURKBNTRK1 | |
| SCHEMBL1331332 | 0.89 | FGFR1 (0.71) | FGFR1DDR2KDRAURKBNTRK1 | |
| SCHEMBL28801366 | 0.88 | FGFR1 (0.54) | FGFR1DDR2KDRAURKBNTRK1 | |
| SCHEMBL1329973 | 0.88 | FGFR1 (0.60) | FGFR1DDR2KDRAURKBNTRK1 | |
| SCHEMBL1331695 | 0.88 | AURKB (0.61) | FGFR1DDR2KDRAURKBNTRK1 | |
| SCHEMBL1330989 | 0.87 | NTRK1 (0.51) | FGFR1DDR2KDRAURKBNTRK1 | |
| SCHEMBL1330605 | 0.82 | NTRK1 (0.53) | FGFR1DDR2KDRAURKBNTRK1 | |
| SCHEMBL1331350 | 0.80 | GSK3B (0.59) | FGFR1DDR2KDRAURKBNTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2569301-A1 | INDAZOLE INHIBITORS OF KINASE | Abbvie Inc. (US) | 2013-03-20 | — | — | EP | disclosed |
| CN-102958927-A | Indazole Inhibitors of Kinases | ABBOTT LAB | 2013-03-06 | — | — | CN | disclosed |
| US-8293738-B2 | Indazole inhibitors of kinase | ABBOTT LABORATORIES (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | disclosed |
| WO-2011143430-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | AURKA, AURKC, AURKB | FGFR1 227/4885DDR2 1265/4885KDR 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.