Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 9/20 | 0.61 |
| ▸ | FLT3 | P36888 | 5/20 | 0.61 |
| ▸ | KIT | P10721 | 4/20 | 0.61 |
| ▸ | AXL | P30530 | 5/20 | 0.60 |
| ▸ | AURKA | O14965 | 4/20 | 0.57 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.57 |
| ▸ | LCK | P06239 | 4/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 3/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.56 |
| ▸ | CDK8 | P49336 | 3/20 | 0.56 |
| ▸ | MET | P08581 | 2/20 | 0.56 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.56 |
| ▸ | PRKX | P51817 | 2/20 | 0.56 |
| ▸ | PIM1 | P11309 | 1/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.56 |
| ▸ | KDR | P35968 | 5/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.55 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.55 |
| ▸ | FYN | P06241 | 3/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1332041 | 0.90 | KDR (0.69) | AURKBFLT3KITAXLAURKA | |
| SCHEMBL1331716 | 0.90 | MAPK1 (0.57) | AURKBFLT3KITAXLAURKA | |
| SCHEMBL1332115 | 0.90 | FGFR1 (0.55) | AURKBFLT3KITAXLAURKA | |
| SCHEMBL1330301 | 0.89 | AXL (0.60) | AURKBFLT3KITAXLAURKA | |
| SCHEMBL1331406 | 0.89 | FGFR1 (0.58) | AURKBFLT3KITAXLAURKA | |
| SCHEMBL1330237 | 0.88 | FGFR1 (0.70) | AURKBFLT3KITAXLAURKA | |
| SCHEMBL1329780 | 0.88 | FGFR1 (0.61) | AURKBFLT3KITAXLNTRK1 | |
| SCHEMBL1330644 | 0.88 | FGFR1 (0.57) | AURKBFLT3KITAXLAURKA | |
| SCHEMBL1331849 | 0.87 | MAPK1 (0.56) | AURKBFLT3KITAXLAURKA | |
| SCHEMBL1329774 | 0.86 | FGFR1 (0.55) | AURKBFLT3KITAXLAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293738-B2 | Indazole inhibitors of kinase | ABBOTT LABORATORIES (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | AURKA, AURKC, AURKB | AURKB 3/4885FLT3 17/4885KIT 119/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.