Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.44 |
| ▸ | PIK3R2 | O00459 | 2/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.44 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.44 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.44 |
| ▸ | PIK3R3 | Q92569 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.35 |
| ▸ | APP | P05067 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12823 | 0.87 | PIK3CD (0.48) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL13190 | 0.81 | PIK3CD (0.46) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL14739 | 0.81 | PIK3CD (0.68) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12276744 | 0.80 | PIK3CD (0.68) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL8169 | 0.75 | THRB (0.46) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL12277121 | 0.73 | PIK3CD (0.67) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG | |
| SCHEMBL18082810 | 0.71 | ALDH1A1 (0.48) | CCNA2CDK2CCNA1ALDH1A1KDM4E | |
| SCHEMBL13184 | 0.70 | ALDH1A1 (0.51) | CCNA2CDK2CCNA1ALDH1A1KDM4E | |
| SCHEMBL18082668 | 0.68 | CCNA2 (0.46) | CCNA2CDK2CCNA1ALDH1A1KDM4E | |
| SCHEMBL18082803 | 0.68 | CCNA2 (0.46) | PIK3CDPIK3R2PIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011058149-A1 | TRICYCLIC PYRAZOL AMINE DERIVATIVES | MERCK SERONO S.A. (CH) | 2011-05-19 | — | — | WO | disclosed |