Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | TP53 | P04637 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13307022 | 0.88 | CFTR (0.46) | MAPTTP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL4478946 | 0.77 | MAPT (0.43) | MAPTTP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL13889574 | 0.71 | KDM4E (0.46) | MAPTKDM4EALDH1A1L3MBTL1HPGD | |
| SCHEMBL31520378 | 0.70 | TP53 (0.45) | MAPTTP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL4397339 | 0.69 | P2RX4 (0.49) | MAPTTP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL14537324 | 0.68 | F2 (0.50) | MAPTTP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL9539742 | 0.66 | AURKA (0.52) | MAPTTP53KDM4ELMNASMN1; SMN2 | |
| SCHEMBL19458501 | 0.65 | PDE1B (0.56) | MAPTKDM4EALDH1A1NPBWR1 | |
| SCHEMBL31014917 | 0.65 | KMT2A (0.60) | MAPTKDM4ELMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL4397609 | 0.64 | HDAC1 (0.46) | MAPTTP53KDM4ELMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2013202-B1 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE | JANSSEN PHARMACEUTICA NV (BE) | 2010-06-16 | — | — | EP | disclosed |