Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
| ▸ | PDE1A | P54750 | 2/20 | 0.46 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.46 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 3/20 | 0.45 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.45 |
| ▸ | PROKR2 | Q8NFJ6 | 1/20 | 0.45 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.45 |
| ▸ | GSK3A | P49840 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.44 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31520378 | 0.77 | TP53 (0.45) | KDM4EALDH1A1MAPTNPBWR1P2RX4 | |
| SCHEMBL4478946 | 0.75 | MAPT (0.43) | KDM4EALDH1A1MAPTALOX15CMA1 | |
| SCHEMBL19458501 | 0.73 | PDE1B (0.56) | KDM4EALDH1A1MAPTALOX15CMA1 | |
| SCHEMBL13307022 | 0.72 | CFTR (0.46) | KDM4EALDH1A1MAPTNPBWR1P2RX4 | |
| SCHEMBL644390 | 0.71 | MAPT (0.49) | KDM4EMAPTCMA1NPBWR1GSK3A | |
| SCHEMBL13307299 | 0.71 | MAPT (0.41) | KDM4EALDH1A1MAPTNPBWR1P2RX4 | |
| SCHEMBL12004096 | 0.69 | KDM4E (0.52) | KDM4EMAPTDCTPP1 | |
| SCHEMBL6078154 | 0.69 | ALDH1A1 (0.48) | KDM4EALDH1A1MAPTALOX15PDE1A | |
| SCHEMBL5901603 | 0.68 | FEN1 (0.48) | KDM4EALDH1A1MAPTALOX15HPGD | |
| SCHEMBL5537580 | 0.68 | CNR1 (0.52) | KDM4EALDH1A1MAPTALOX15PDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090111801-A1 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-04-30 | — | — | US | disclosed |
| US-20080269251-A1 | Substituted Pyrazinone Derivatives as Alpha2C-Adrenoreceptor Antagonists | ANDRE-GIL JOSE IGNACIO | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090111801-A1 | SUBSTITUTED PYRAZINONE DERIVATIVES FOR USE AS A MEDICINE | ADRA2C, ADRB2, CHRNA5 | KDM4E 3069/4885ALDH1A1 710/4885MAPT 236/4885 |
| US-20080269251-A1 | Substituted Pyrazinone Derivatives as Alpha2C-Adrenoreceptor Antagonists | ADRA2C, ADRB2, ADRA2A | KDM4E 3808/4885ALDH1A1 568/4885MAPT 426/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.