Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | USP2 | O75604 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3989442 | 0.84 | NPBWR1 (0.41) | MAPTRXFP1ALDH1A1SMN1; SMN2USP2 | |
| SCHEMBL13307022 | 0.78 | CFTR (0.46) | MAPTKMT2AP2RX4ALDH1A1SMN1; SMN2 | |
| SCHEMBL13307299 | 0.77 | MAPT (0.41) | MAPTKMT2AP2RX4ALDH1A1SMN1; SMN2 | |
| SCHEMBL3986121 | 0.76 | SMN1; SMN2 (0.39) | MEN1KMT2AALDH1A1SMN1; SMN2HSD17B10 | |
| SCHEMBL13889574 | 0.75 | KDM4E (0.46) | MAPTP2RX4ALDH1A1TSHRHPGD | |
| SCHEMBL31520378 | 0.74 | TP53 (0.45) | MAPTMEN1KMT2AP2RX4ALDH1A1 | |
| SCHEMBL25433242 | 0.73 | KDM4E (0.48) | MAPTRXFP1P2RX4ALDH1A1CYP1A2 | |
| SCHEMBL31208038 | 0.73 | KDM4E (0.48) | MAPTRXFP1P2RX4ALDH1A1CYP1A2 | |
| SCHEMBL4486345 | 0.70 | TRAP1 (0.37) | MAPTKMT2ASMN1; SMN2USP2TSHR | |
| SCHEMBL3986813 | 0.70 | TRAP1 (0.37) | MAPTKMT2ASMN1; SMN2USP2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2009-07-23 | — | — | US | disclosed |
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | SHARPE PAULA LOUISE | 2008-08-14 | — | — | US | disclosed |
| EP-1848711-A1 | FUNGICIDAL PYRAZINE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089060-A1 | FUNGICIDAL PYRAZINE DERIVATIVES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | CBR3, CBR1, NR0B1 | MAPT 4494/4885MEN1 2439/4885KMT2A 4532/4885 |
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | MKI67, NR0B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | MAPT 4590/4885MEN1 2022/4885KMT2A 4452/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.