Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 10/20 | 0.85 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.85 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.62 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.62 |
| ▸ | PRKCG | P05129 | 1/20 | 0.62 |
| ▸ | PIM1 | P11309 | 1/20 | 0.62 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.62 |
| ▸ | AKT1 | P31749 | 1/20 | 0.62 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.62 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.62 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.62 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.62 |
| ▸ | STK3 | Q13188 | 1/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.62 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.62 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.62 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.62 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.61 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2439661 | 1.00 | CHRNB2 (0.85) | CHRNB2CHRNA4DAPK3ROCK2PRKCG | |
| Hydrochloric Acid SCHEMBL7459220 | 0.99 | CHRNB2 (0.82) | CHRNB2CHRNA4DAPK3ROCK2PRKCG | |
| SCHEMBL2439794 | 0.92 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL7668967 | 0.92 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL6587460 | 0.92 | CHRNB2 (1.00) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| Hydrochloric Acid SCHEMBL7460621 | 0.91 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| Hydrochloric Acid SCHEMBL7411062 | 0.91 | CHRNB2 (0.97) | CHRNB2CHRNA4CHRNA3CHRNB4CHRNB1 | |
| SCHEMBL13308144 | 0.84 | CHRNB2 (0.84) | CHRNB2CHRNA4DAPK3ROCK2PRKCG | |
| SCHEMBL7409960 | 0.84 | CHRNB2 (0.64) | CHRNB2CHRNA4DAPK3ROCK2PRKCG | |
| SCHEMBL7408002 | 0.84 | CHRNB2 (0.64) | CHRNB2CHRNA4DAPK3ROCK2PRKCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130184313-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2013-07-18 | — | — | US | disclosed |
| US-8445684-B2 | Nicotinic acetylcholine receptor ligands and the uses thereof | PsycoGenics Inc. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20100152450-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF | PSYCHOGENICS, INC. (US) | 2010-06-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100152450-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF | CHRNG, CHRNA5, CHRNA2 | CHRNB2 12/4885CHRNA4 5/4885DAPK3 1399/4885 |
| US-20130184313-A1 | NICOTINIC ACETYLCHOLINE RECEPTOR LIGANDS AND THE USES THEREOF | CHRNG, CHRNA5, CHRNA2 | CHRNB2 12/4885CHRNA4 5/4885DAPK3 1399/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.