Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 11/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13309406 | 0.88 | GPR119 (0.44) | PIK3CDGPR119 | |
| SCHEMBL11931565 | 0.86 | CHEK1 (0.52) | PIK3CDGPR119IRAK1CHEK1CCNA2 | |
| SCHEMBL13309257 | 0.84 | IRAK1 (0.44) | GPR119IRAK1CHEK1USP30CCNA2 | |
| SCHEMBL11931348 | 0.82 | IRAK1 (0.45) | PIK3CDGPR119IRAK1CHEK1USP30 | |
| SCHEMBL11931350 | 0.81 | IRAK1 (0.43) | GPR119IRAK1CHEK1USP30CCNA2 | |
| SCHEMBL14516698 | 0.80 | CHEK1 (0.43) | PIK3CDGPR119IRAK1CHEK1USP30 | |
| SCHEMBL11931080 | 0.80 | IRAK1 (0.40) | GPR119IRAK1CHEK1USP30CCNA2 | |
| SCHEMBL11931349 | 0.79 | IRAK1 (0.46) | PIK3CDGPR119IRAK1CHEK1USP30 | |
| SCHEMBL11931356 | 0.78 | IRAK1 (0.48) | GPR119IRAK1CHEK1USP30CCNA2 | |
| SCHEMBL14218639 | 0.78 | IRAK1 (0.48) | PIK3CDGPR119IRAK1CHEK1USP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934224-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS FOR THE TREATMENT OF CANCER | SCHERING CORP (US) | 2010-06-09 | — | — | EP | disclosed |
| US-7205308-B2 | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-04-17 | — | — | US | disclosed |