Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.35 |
| ▸ | FPR2 | P25090 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | PDE2A | O00408 | 1/20 | 0.33 |
| ▸ | HPGDS | O60760 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCND2 | P30279 | 1/20 | 0.32 |
| ▸ | CCND3 | P30281 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13309405 | 0.88 | PIK3CD (0.41) | GPR119PIK3CD | |
| SCHEMBL13309478 | 0.84 | GPR119 (0.44) | GPR119PIK3CDTRPV3FPR2CYP2C9 | |
| SCHEMBL14519195 | 0.83 | TRPV3 (0.37) | TRPV3FPR2HPGDSJAK2PRMT5 | |
| SCHEMBL14561897 | 0.79 | TRPV3 (0.36) | PIK3CDTRPV3FPR2HPGDSJAK2 | |
| SCHEMBL14561898 | 0.78 | ALDH1A1 (0.37) | GPR119TRPV3HPGDSMEN1ALDH1A1 | |
| SCHEMBL13309134 | 0.76 | TRPV3 (0.39) | TRPV3FPR2HPGDSJAK2MEN1 | |
| SCHEMBL14541613 | 0.75 | TRPV3 (0.43) | PIK3CDTRPV3FPR2HPGDSJAK2 | |
| SCHEMBL14942244 | 0.75 | CHEK1 (0.53) | TRPV3FPR2HPGDSJAK2JAK1 | |
| SCHEMBL11931323 | 0.75 | TRPV3 (0.43) | TRPV3FPR2CYP2C9HPGDSJAK2 | |
| SCHEMBL11931324 | 0.74 | TRPV3 (0.42) | TRPV3FPR2CYP2C9HPGDSJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1934224-B1 | PYRAZOLOPYRIMIDINES AS CYCLIN DEPENDENT KINASE INHIBITORS FOR THE TREATMENT OF CANCER | SCHERING CORP (US) | 2010-06-09 | — | — | EP | disclosed |
| US-7205308-B2 | Trisubstituted 7-aminopyrazolopyrimidines as cyclin dependent kinase inhibitors | SCHERING CORPORATION (US) | 2007-04-17 | — | — | US | disclosed |