Diphenylurea

Diphenylurea

SCHEMBL133103

O=C(Nc1ccccc1)Nc1ccccc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 1.00
TP53 P04637 1/20 1.00
EPHX1 P07099 1/20 1.00
TSHR P16473 1/20 1.00
EPHX2 P34913 1/20 1.00
CDK9 P50750 1/20 1.00
CLK4 Q9HAZ1 1/20 1.00
CASP3 P42574 1/20 0.81
SENP7 Q9BQF6 1/20 0.81
MAOA P21397 2/20 0.77
MAOB P27338 2/20 0.77
RAB9A P51151 7/20 0.74
KMT2A Q03164 7/20 0.74
NPC1 O15118 6/20 0.74
TAAR1 Q96RJ0 3/20 0.74
SIRT1 Q96EB6 1/20 0.71
MEN1 O00255 5/20 0.68
MAPT P10636 4/20 0.68
NPSR1 Q6W5P4 1/20 0.68
LMNA P02545 2/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Diphenylurea SCHEMBL3037927 0.97 SMN1; SMN2 (0.94) SMN1; SMN2TP53EPHX1TSHREPHX2
Diphenylurea SCHEMBL28431956 0.97 SMN1; SMN2 (0.94) SMN1; SMN2TP53EPHX1TSHREPHX2
Diphenylurea SCHEMBL29392345 0.97 SMN1; SMN2 (0.94) SMN1; SMN2TP53EPHX1TSHREPHX2
Diphenylurea SCHEMBL30786615 0.97 SMN1; SMN2 (0.94) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL11059378 0.97 SMN1; SMN2 (0.94) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL20804375 0.92 SMN1; SMN2 (0.85) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL12010916 0.90 CASP3 (1.00) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL21810514 0.90 SMN1; SMN2 (0.81) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL17193484 0.90 TP53 (0.81) SMN1; SMN2TP53EPHX1TSHREPHX2
SCHEMBL9479905 0.90 CASP3 (1.00) SMN1; SMN2TP53EPHX1TSHREPHX2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 8284 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4743311-A1 PHENOL-FREE, HEAT-SENSITIVE RECORDING MATERIAL Oji Holdings Corporation (JP) 2026-05-20 EP claimed
EP-4536613-B1 COMBUSTIBLE PROPELLANT CHARGE CASE NITROCHEMIE GMBH (DE) 2026-05-20 EP claimed
CN-122042838-A Application of gestational late urine metabolic marker of gestational diabetes and kit 上海市第一人民医院 2026-05-15 CN claimed
US-20260132275-A1 RUBBER COMPOSITION BASED ON PYROLYSIS CARBON BLACK AND EPOXY RESIN CIE GENERALE DES ETABLISSEMENTS MICHELIN (FR) 2026-05-14 US claimed
EP-4493417-B1 RUBBER COMPOSITION COMPRISING AN EPOXY RESIN AND A HARDENER MICHELIN & CIE (FR) 2026-05-06 EP claimed
US-20260110523-A1 COMBUSTIBLE PROPELLANT CHARGE SLEEVE NITROCHEMIE GMBH (DE) 2026-04-23 US claimed
US-12545045-B2 Direct thermal recording media with diarylurea combinations for oil resistance APPVION, LLC (US) 2026-02-10 US claimed
US-20260034050-A1 COMPOSITIONS AND USES OF ALPHA-ADRENERGIC AGENTS LEVATION PHARMA LTD (US) 2026-02-05 US claimed
US-12540212-B2 Synthesis of polyurethane polymers in flow reactors INTERNATIONAL BUSINESS MACHINES CORPORATION (US) 2026-02-03 US claimed
EP-4638538-A1 LIQUID RHEOLOGY CONTROL AGENT BYK-Chemie GmbH (DE) 2025-10-29 EP claimed
US-4246361-A Method for producing flame- and smoke-resistant polyurethane foam sheet by incorporation of a urea derivative in reaction mixture BRIDGESTONE TIRE CO., LTD. (JP) 1981-01-20 US claimed
EP-0015110-A2 Anticoccidial composition, carbanilides and method of preparing them ELI LILLY AND COMPANY (US) 1980-09-03 EP claimed
US-4197318-A CYCLOHEXYL SUBSTITUTED ALKANOLS AS POTENTIATORS JOHNSON & JOHNSON (US) 1980-04-08 US claimed
US-4180405-A COLOR-FORMING LACTONES OR SPIROPYRANS WITH CYCLIC POLYKETO COLOR PRECURSOR GRAPHIC CONTROLS CORPORATION (US) 1979-12-25 US claimed
US-4180631-A Flame-and smoke-resistant flexible polyurethane foam and compressed foam sheet BRIDGESTONE TIRE COMPANY, LIMITED (JP) 1979-12-25 US claimed
US-4120948-A Two phase antiperspirant compositions THE PROCTER & GAMBLE COMPANY (US) 1978-10-17 US claimed
US-4097288-A Heat sensitive recording composition containing a complexed phenolics and a spiropyran or leuco lactone GRAPHIC CONTROLS CORPORATION 1978-06-27 US claimed
US-3976501-A EMULSION COPOLYMER, BINDER RESIN, BACTERIOSTAT BLUE MAURICE R 1976-08-24 US claimed
US-3956510-A NESTING, CYLINDERS, LOOPS BEALL NELSON J 1976-05-11 US claimed
US-3947412-A CYCLIZATION IN THE PRESENCE OF HEAVY METALS BAYER AKTIENGESELLSCHAFT (DT) 1976-03-30 US claimed