Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ALPL | P05186 | 1/20 | 0.34 |
| ▸ | ALPI | P09923 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20047485 | 0.85 | UGT2B7 (0.38) | CYP2C19CYP17A1CYP2C9UGT2B7CYP2D6 | |
| SCHEMBL14072410 | 0.78 | UGT2B7 (0.34) | CYP2C19CYP17A1CYP2C9UGT2B7MEN1 | |
| SCHEMBL13347770 | 0.77 | CYP1A2 (0.48) | CYP1A2TRPV4ADRA2A | |
| SCHEMBL13677499 | 0.75 | UGT2B7 (0.41) | UGT2B7CYP2D6TSHRMEN1CYP1A2 | |
| SCHEMBL13677552 | 0.75 | CYP1A2 (0.53) | UGT2B7CYP2D6TSHRMEN1CYP1A2 | |
| SCHEMBL13310563 | 0.75 | NPC1 (0.39) | CYP2C19CYP17A1CYP2C9UGT2B7CYP2D6 | |
| SCHEMBL2609310 | 0.74 | TRPV4 (0.52) | CYP2C19CYP2C9CYP2D6TSHRCYP3A4 | |
| SCHEMBL10090610 | 0.74 | CYP2D6 (0.45) | UGT2B7CYP2D6TSHRMEN1CYP1A2 | |
| SCHEMBL20370830 | 0.74 | PDPK1 (0.52) | UGT2B7CYP2D6TSHRMEN1CYP1A2 | |
| SCHEMBL179263 | 0.73 | LOXL2 (0.47) | TLR7MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8309544-B2 | Spiroindalones | MERCK SHARP & DOHME CORP. (US) | 2012-11-13 | — | — | US | disclosed |
| US-20100137297-A1 | SPIROINDALONES | MERCK SHARP & DOHME LLC | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137297-A1 | SPIROINDALONES | HIF1AN, HIF1A, EGLN2 | CYP2C19 2406/4885CYP17A1 77/4885CYP2C9 2986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.