Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.65 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.61 |
| ▸ | BACE1 | P56817 | 7/20 | 0.59 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.55 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.55 |
| ▸ | CCR5 | P51681 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | CALM1 | P0DP23 | 2/20 | 0.54 |
| ▸ | P4HB | P07237 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | F3 | P13726 | 1/20 | 0.54 |
| ▸ | XDH | P47989 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1573468 | 0.89 | AKR1B10 (0.69) | BACE1AKR1B1MAOBAKR1B10PTGS2 | |
| SCHEMBL1573466 | 0.89 | AKR1B10 (0.69) | BACE1AKR1B1MAOBAKR1B10PTGS2 | |
| SCHEMBL14864159 | 0.87 | GSK3B (0.87) | GSK3BBACE1AKR1B1MAOBAKR1B10 | |
| SCHEMBL13745604 | 0.86 | MAOB (0.59) | BACE1AKR1B1MAOBAKR1B10PTGS2 | |
| SCHEMBL18509212 | 0.84 | GSK3B (0.71) | GSK3BF2RL1BACE1CCR5MAPT | |
| SCHEMBL17019815 | 0.83 | ABCB1 (0.76) | GSK3BBACE1AKR1B1MAOBPTGS2 | |
| SCHEMBL17019816 | 0.83 | ABCB1 (0.72) | GSK3BBACE1AKR1B1MAOBPTGS2 | |
| SCHEMBL13746120 | 0.83 | BACE1 (0.61) | BACE1AKR1B1MAOBAKR1B10PTGS2 | |
| SCHEMBL3210848 | 0.82 | BACE1 (0.71) | BACE1AKR1B1AKR1B10MAPTRAB9A | |
| SCHEMBL3210831 | 0.82 | BACE1 (0.71) | BACE1AKR1B1AKR1B10MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7728043-B2 | Methods for treatment of beta-amyloid protein-induced ocular disease | KIM DARRICK S H L | 2010-06-01 | — | — | US | disclosed |