Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | PDE5A | O76074 | 1/20 | 0.43 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.40 |
| ▸ | TOP1 | P11387 | 1/20 | 0.40 |
| ▸ | ATP4A | P20648 | 1/20 | 0.40 |
| ▸ | ATP4B | P51164 | 1/20 | 0.40 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MPO | P05164 | 2/20 | 0.39 |
| ▸ | TPO | P07202 | 1/20 | 0.39 |
| ▸ | EPX | P11678 | 1/20 | 0.39 |
| ▸ | MGMT | P16455 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13313396 | 0.82 | L3MBTL1 (0.48) | L3MBTL1CYP3A4PDE5AHRH4HTT | |
| SCHEMBL13313397 | 0.81 | L3MBTL1 (0.43) | L3MBTL1CYP3A4PDE5AHRH4HTT | |
| SCHEMBL13313393 | 0.81 | L3MBTL1 (0.43) | L3MBTL1CYP3A4PDE5AHRH4HTT | |
| SCHEMBL13348647 | 0.79 | TLR8 (0.42) | L3MBTL1CYP3A4HTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL13313406 | 0.75 | CYP3A4 (0.46) | L3MBTL1CYP3A4LTA4HMAPK14HTT | |
| SCHEMBL1775713 | 0.74 | L3MBTL1 (0.51) | L3MBTL1CYP3A4PDE5AHRH4LTA4H | |
| SCHEMBL13313401 | 0.74 | L3MBTL1 (0.48) | L3MBTL1PDE5AHRH4HTTSTAT3 | |
| SCHEMBL2400247 | 0.73 | L3MBTL1 (0.47) | L3MBTL1CYP3A4PDE5AHRH4LTA4H | |
| SCHEMBL312251 | 0.73 | CYP3A4 (0.49) | L3MBTL1CYP3A4PDE5AHRH4LTA4H | |
| SCHEMBL16541498 | 0.72 | PRMT5 (0.45) | L3MBTL1CYP3A4HTTTOP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100160346-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS | PRANA BIOTECHNOLOGY LIMITED (AU) | 2010-06-24 | — | — | US | disclosed |
| US-7692011-B2 | 8-hydroxy and 8-mercapto quinazolinones | PRANA BIOTECHNOLOGY LIMITED (AU) | 2010-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100160346-A1 | NEUROLOGICALLY ACTIVE COMPOUNDS | ACHE, PSEN1, PSEN2 | L3MBTL1 2272/4885CYP3A4 3007/4885PDE5A 1217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.