Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 5/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 5/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11735334 | 0.86 | LMNA (0.77) | LMNACYP2C19GLAALDH1A1MAPK1 | |
| SCHEMBL4873214 | 0.84 | LMNA (0.75) | LMNACYP2C19GLAALDH1A1MAPK1 | |
| Ronidazole SCHEMBL635714 | 0.84 | LMNA (1.00) | LMNACYP2C19GLAALDH1A1MAPK1 | |
| SCHEMBL31018740 | 0.82 | LMNA (0.67) | LMNACYP2C19GLAALDH1A1MAPK1 | |
| SCHEMBL31018738 | 0.82 | LMNA (0.67) | LMNACYP2C19GLAALDH1A1MAPK1 | |
| SCHEMBL7556049 | 0.81 | LMNA (0.62) | LMNACYP2C19ALDH1A1MAPTKMT2A | |
| SCHEMBL15752503 | 0.81 | LMNA (0.68) | LMNACYP2C19GLAALDH1A1MAPK1 | |
| SCHEMBL11641368 | 0.79 | LMNA (0.67) | LMNACYP2C19GLAALDH1A1MAPT | |
| SCHEMBL11493231 | 0.78 | LMNA (0.58) | LMNACYP2C19GLAALDH1A1MAPK1 | |
| SCHEMBL11637096 | 0.78 | LMNA (0.65) | LMNACYP2C19ALDH1A1MAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8980907-B2 | Dendrimer conjugates | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2015-03-17 | — | — | US | disclosed |
| US-8889635-B2 | Dendrimer conjugates | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-11-18 | — | — | US | disclosed |
| US-20140128327-A1 | DENDRIMER CONJUGATES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2014-05-08 | — | — | US | disclosed |
| US-20100160299-A1 | DENDRIMER CONJUGATES | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2010-06-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140128327-A1 | DENDRIMER CONJUGATES | CD44, DDOST, ADGRE5 | LMNA 3032/4885CYP2C19 4289/4885GLA 2986/4885 |
| US-20100160299-A1 | DENDRIMER CONJUGATES | CD44, DDOST, ADGRE5 | LMNA 3032/4885CYP2C19 4289/4885GLA 2986/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.