Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 8/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.53 |
| ▸ | LCK | P06239 | 3/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 3/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.53 |
| ▸ | CDK8 | P49336 | 2/20 | 0.53 |
| ▸ | PRKX | P51817 | 2/20 | 0.53 |
| ▸ | MET | P08581 | 1/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.53 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 6/20 | 0.53 |
| ▸ | KIT | P10721 | 5/20 | 0.51 |
| ▸ | FLT3 | P36888 | 4/20 | 0.51 |
| ▸ | FYN | P06241 | 2/20 | 0.51 |
| ▸ | CSF1R | P07333 | 2/20 | 0.51 |
| ▸ | LYN | P07948 | 2/20 | 0.51 |
| ▸ | FLT1 | P17948 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1331695 | 0.84 | AURKB (0.61) | NTRK1AURKBLCKPDGFRAAURKA | |
| SCHEMBL1331712 | 0.81 | NTRK1 (0.59) | NTRK1AURKBLCKPDGFRAAURKA | |
| SCHEMBL1331406 | 0.81 | FGFR1 (0.58) | NTRK1AURKBLCKPDGFRAAURKA | |
| SCHEMBL1330644 | 0.80 | FGFR1 (0.57) | NTRK1AURKBLCKPDGFRAAURKA | |
| SCHEMBL1331706 | 0.79 | NTRK1 (0.82) | NTRK1AURKBLCKPDGFRAAURKA | |
| SCHEMBL1332000 | 0.79 | NTRK1 (0.58) | NTRK1AURKBLCKPDGFRAAURKA | |
| SCHEMBL1330605 | 0.78 | NTRK1 (0.53) | NTRK1AURKBLCKPDGFRAAURKA | |
| SCHEMBL1330989 | 0.78 | NTRK1 (0.51) | NTRK1AURKBLCKPDGFRAAURKA | |
| SCHEMBL1329973 | 0.77 | FGFR1 (0.60) | NTRK1AURKBLCKPDGFRAAURKA | |
| SCHEMBL1330849 | 0.76 | KDR (0.56) | NTRK1AURKBLCKPDGFRAAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293738-B2 | Indazole inhibitors of kinase | ABBOTT LABORATORIES (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | ABBOTT LABORATORIES (US) | 2011-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110281868-A1 | INDAZOLE INHIBITORS OF KINASE | AURKA, AURKC, AURKB | NTRK1 805/4885AURKB 3/4885LCK 185/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.