Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 6/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 6/20 | 0.36 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | SLC27A1 | Q6PCB7 | 2/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13314765 | 0.93 | MAPT (0.37) | NPC1RAB9ATSHRLMNAMAPT | |
| SCHEMBL3531836 | 0.93 | MAPT (0.37) | NPC1RAB9ATSHRLMNAMAPT | |
| SCHEMBL3542473 | 0.79 | RAB9A (0.44) | NPC1RAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL13314762 | 0.79 | RAB9A (0.44) | NPC1RAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL16993688 | 0.76 | MAPT (0.31) | NPC1RAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL3532844 | 0.74 | RAB9A (0.52) | NPC1RAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL13314761 | 0.74 | RAB9A (0.52) | NPC1RAB9ALMNAMAPTALDH1A1 | |
| SCHEMBL3536095 | 0.73 | TSHR (0.58) | NPC1RAB9ATSHRLMNAMAPT | |
| SCHEMBL13314772 | 0.73 | TSHR (0.54) | NPC1RAB9ATSHRLMNAMAPT | |
| SCHEMBL13314773 | 0.72 | TSHR (0.56) | NPC1RAB9ATSHRLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |