Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | SLC27A1 | Q6PCB7 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 4/20 | 0.31 |
| ▸ | HRH2 | P25021 | 2/20 | 0.31 |
| ▸ | HRH1 | P35367 | 2/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3531836 | 1.00 | MAPT (0.37) | MAPTLMNASLC27A1RAB9ANPC1 | |
| SCHEMBL13314767 | 0.93 | NPC1 (0.37) | MAPTLMNASLC27A1RAB9ANPC1 | |
| SCHEMBL13314762 | 0.83 | RAB9A (0.44) | MAPTLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3542473 | 0.83 | RAB9A (0.44) | MAPTLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL3532844 | 0.78 | RAB9A (0.52) | MAPTLMNASLC27A1RAB9ANPC1 | |
| SCHEMBL13314761 | 0.78 | RAB9A (0.52) | MAPTLMNASLC27A1RAB9ANPC1 | |
| SCHEMBL4421639 | 0.74 | RAB9A (0.44) | MAPTLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL13570298 | 0.72 | MAPT (0.47) | MAPTLMNARAB9ANPC1SMN1; SMN2 | |
| SCHEMBL11241158 | 0.72 | DRD2 (0.45) | HRH2HRH1HRH4HRH3DRD2 | |
| SCHEMBL16993688 | 0.71 | MAPT (0.31) | MAPTLMNARAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |