Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSEN1 | P49768 | 9/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 9/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 9/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 9/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 9/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 9/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.36 |
| ▸ | SLC12A5 | Q9H2X9 | 1/20 | 0.36 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3538635 | 1.00 | PSEN1 (0.39) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Formic Acid SCHEMBL3539296 | 0.95 | ALDH1A1 (0.37) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3539299 | 0.84 | ALDH1A1 (0.35) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3536165 | 0.82 | NPC1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3536663 | 0.82 | NPC1 (0.34) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3537650 | 0.80 | PSEN1 (0.59) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL13314793 | 0.79 | F2 (0.44) | ALDH1A1POLBMAPTRAB9AGAA | |
| SCHEMBL3536190 | 0.79 | F2 (0.44) | ALDH1A1POLBMAPTRAB9AGAA | |
| SCHEMBL13314776 | 0.78 | NPC1 (0.32) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3536970 | 0.78 | NOS1 (0.33) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |
| US-7727979-B2 | Guanidine derivatives and their use as neuropeptide FF receptor antagonists | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-06-01 | — | — | US | disclosed |