Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EIF2AK2 | P19525 | 2/20 | 0.48 |
| ▸ | CHUK | O15111 | 6/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ICOSLG | O75144 | 4/20 | 0.45 |
| ▸ | ICOS | Q9Y6W8 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.43 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1798417 | 0.78 | CHUK (0.73) | CHUKALDH1A1ICOSLGICOSKDM4E | |
| SCHEMBL10556274 | 0.71 | ALDH1A1 (0.71) | EIF2AK2ALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL1798096 | 0.70 | CHUK (0.56) | CHUKICOSLGICOSCYP1A2CYP3A4 | |
| SCHEMBL13377082 | 0.67 | CHUK (0.72) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL10560487 | 0.66 | ADRA2C (0.68) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| Chloromethane SCHEMBL10559568 | 0.66 | ALDH1A1 (0.71) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL10559382 | 0.66 | KDM4E (0.71) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL13847805 | 0.66 | CHUK (0.70) | CHUKICOSLGICOSMEN1IKBKB | |
| SCHEMBL10557452 | 0.65 | POLB (0.66) | ALDH1A1KDM4EMEN1KMT2APOLB | |
| SCHEMBL10557404 | 0.65 | ALDH1A1 (0.74) | ALDH1A1KDM4EMEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7727985-B2 | Beta-carbolines useful for treating inflammatory disease | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |
| US-7727985-B2 | Beta-carbolines useful for treating inflammatory disease | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2010-06-01 | — | — | US | disclosed |