Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CNR2 | P34972 | 4/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.42 |
| ▸ | PDE4A | P27815 | 2/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.36 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13315956 | 0.90 | ALDH1A1 (0.48) | ALDH1A1CYP1A2CYP2C19CNR2MTNR1A | |
| SCHEMBL13315954 | 0.77 | ALDH1A1 (0.44) | ALDH1A1CYP1A2CYP2C19PDE4APDE4B | |
| SCHEMBL4252996 | 0.72 | KAT2B (0.45) | ALDH1A1CYP1A2CYP2C19CNR2KDM4E | |
| SCHEMBL4767726 | 0.72 | CNR2 (0.57) | ALDH1A1CNR2KDM4EADRA2A | |
| SCHEMBL2336285 | 0.70 | ALDH1A1 (0.45) | ALDH1A1CNR2PDE4APDE4BPDE4C | |
| SCHEMBL12667303 | 0.70 | ALDH1A1 (0.46) | ALDH1A1CYP1A2CYP2C19CNR2PDE4A | |
| SCHEMBL25980052 | 0.68 | MAPT (0.62) | ALDH1A1LMNAKDM4EMAPTHPGD | |
| SCHEMBL13349387 | 0.68 | ALDH1A1 (0.41) | ALDH1A1CNR2PDE4APDE4BPDE4C | |
| SCHEMBL1948066 | 0.68 | ADORA2B (0.46) | ALDH1A1CNR2PDE4APDE4BPDE4C | |
| SCHEMBL10502022 | 0.68 | ADORA2A (0.44) | ALDH1A1CYP1A2CYP2C19CNR2PDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144764-A1 | PYRIMIDINEDIONE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
| WO-2008127591-A2 | PYRIMIDINEDIONE DERIVATIVES AND USE THEREOF | SCHERING CORPORATION (US) | 2008-10-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144764-A1 | PYRIMIDINEDIONE DERIVATIVES AND METHODS OF USE THEREOF | DPYD, TYMS, FPGS | ALDH1A1 99/4885CYP1A2 279/4885CYP2C19 245/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.