Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13316674 | 0.86 | NPC1 (0.34) | DHFRKDM4C | |
| SCHEMBL13349708 | 0.80 | CASR (0.32) | — | |
| SCHEMBL13316571 | 0.78 | DHFR (0.33) | DHFRL3MBTL1KDM4C | |
| SCHEMBL13316572 | 0.77 | KDM4C (0.36) | DHFRL3MBTL1KDM4C | |
| SCHEMBL13316575 | 0.76 | KDM4C (0.35) | DHFRL3MBTL1KDM4C | |
| SCHEMBL13316632 | 0.76 | KDM4C (0.36) | DHFRL3MBTL1KDM4C | |
| SCHEMBL13349620 | 0.75 | DHFR (0.33) | DHFRL3MBTL1KDM4C | |
| SCHEMBL13349598 | 0.69 | CXCR2 (0.32) | — | |
| SCHEMBL13316633 | 0.69 | KDM4C (0.36) | DHFRL3MBTL1KDM4C | |
| SCHEMBL13349597 | 0.68 | CXCR2 (0.34) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |