Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.33 |
| ▸ | FEN1 | P39748 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.32 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 5/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13316575 | 0.90 | KDM4C (0.35) | KDM4CL3MBTL1DHFRALOX5APFEN1 | |
| SCHEMBL13316632 | 0.84 | KDM4C (0.36) | KDM4CL3MBTL1DHFRALOX5APFEN1 | |
| SCHEMBL13316572 | 0.79 | KDM4C (0.36) | KDM4CL3MBTL1DHFRMEN1KMT2A | |
| SCHEMBL13349669 | 0.76 | MPO (0.32) | — | |
| SCHEMBL13316571 | 0.75 | DHFR (0.33) | KDM4CL3MBTL1DHFRNPC1RAB9A | |
| SCHEMBL13349620 | 0.74 | DHFR (0.33) | KDM4CL3MBTL1DHFRNPC1RAB9A | |
| SCHEMBL6577520 | 0.69 | SLC6A3 (0.44) | KDM4CL3MBTL1MEN1KMT2ANPC1 | |
| SCHEMBL13316613 | 0.69 | DHFR (0.32) | KDM4CL3MBTL1DHFR | |
| SCHEMBL13316635 | 0.68 | PDE3B (0.36) | KDM4CL3MBTL1 | |
| SCHEMBL23834996 | 0.64 | L3MBTL1 (0.44) | KDM4CL3MBTL1MEN1KMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745459-B2 | Quinolizinone compound and use thereof as HIV integrase inhibitor | JAPAN TOBACCO INC. (JP) | 2010-06-29 | — | — | US | disclosed |