SCHEMBL13318552

SCHEMBL13318552

COC(=O)NNC(=O)c1cc(Cl)cc(I)c1NC(=O)c1cc(Br)nn1-c1ncccc1Cl

nearest known ligand 0.65

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ DHODH Q02127 3/20 0.42
▸ ALDH1A1 P00352 1/20 0.36
▸ MEN1 O00255 1/20 0.33
▸ KMT2A Q03164 1/20 0.33
▸ RBP4 P02753 1/20 0.33
▸ MALT1 Q9UDY8 6/20 0.31
▸ TSHR P16473 1/20 0.31
▸ HSD17B10 Q99714 1/20 0.31
▸ TRPV1 Q8NER1 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13072491 0.92 DHODH (0.41) DHODHALDH1A1MEN1KMT2ARBP4
SCHEMBL12911659 0.92 DHODH (0.41) DHODHMEN1KMT2ARBP4MALT1
SCHEMBL13073075 0.92 DHODH (0.41) DHODHALDH1A1MEN1KMT2ARBP4
SCHEMBL120729 0.91 DHODH (0.42) DHODHALDH1A1MEN1KMT2ARBP4
SCHEMBL13318549 0.90 DHODH (0.45) DHODHALDH1A1RBP4MALT1
SCHEMBL12559834 0.89 DHODH (0.39) DHODHALDH1A1MEN1KMT2ARBP4
SCHEMBL461817 0.88 DHODH (0.45) DHODHALDH1A1MEN1KMT2ARBP4
SCHEMBL13072490 0.87 DHODH (0.46) DHODHALDH1A1MEN1KMT2ARBP4
SCHEMBL535381 0.86 DHODH (0.42) DHODHALDH1A1MEN1KMT2ARBP4
SCHEMBL121385 0.86 DHODH (0.41) DHODHALDH1A1MEN1KMT2ARBP4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20100137314-A1 HARMFUL ORGANISM CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 — — US disclosed
US-20100137314-A1 HARMFUL ORGANISM CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-06-03 — — US disclosed
US-20100099692-A1 HARMFUL ORGANISM CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-22 — — US disclosed
US-20100099692-A1 HARMFUL ORGANISM CONTROL COMPOSITION SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 2010-04-22 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100099692-A1 HARMFUL ORGANISM CONTROL COMPOSITION UQCRC1, UQCRC2, Q6ZSR9 DHODH 277/4885ALDH1A1 280/4885MEN1 2791/4885
US-20100137314-A1 HARMFUL ORGANISM CONTROL COMPOSITION UQCRC2, UQCRC1, UQCRB DHODH 558/4885ALDH1A1 217/4885MEN1 3045/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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