Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 4/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13003276 | 0.89 | ACKR3 (0.44) | CYP3A4TBK1MAPK1 | |
| SCHEMBL13319049 | 0.88 | MAPK1 (0.57) | CYP3A4TBK1MAPK1NPSR1 | |
| SCHEMBL14095261 | 0.87 | CYP3A4 (0.42) | CYP3A4TBK1MAPK1NPSR1 | |
| SCHEMBL13319051 | 0.86 | SRPK1 (0.46) | MAPK1NPSR1 | |
| SCHEMBL13003288 | 0.79 | MAPK1 (0.46) | TBK1MAPK1NPSR1 | |
| SCHEMBL13003272 | 0.79 | MAPK1 (0.47) | TBK1MAPK1NPSR1 | |
| SCHEMBL13003280 | 0.77 | ACKR3 (0.42) | CYP3A4TBK1 | |
| SCHEMBL13003284 | 0.76 | ACKR3 (0.42) | CYP3A4TBK1MAPK1 | |
| SCHEMBL14095127 | 0.76 | MAPK1 (0.55) | TBK1MAPK1NPSR1 | |
| SCHEMBL13060200 | 0.76 | ACKR3 (0.45) | CYP3A4TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100144591-A1 | BENZIMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION | 2010-06-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100144591-A1 | BENZIMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF | GPR119, GK, GCK | CYP3A4 339/4885TBK1 160/4885MAPK1 2152/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.