Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | TBK1 | Q9UHD2 | 7/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14095127 | 0.89 | MAPK1 (0.55) | TBK1MAPK1NPSR1 | |
| SCHEMBL13319050 | 0.87 | CYP3A4 (0.43) | CYP3A4TBK1MAPK1NPSR1 | |
| SCHEMBL14095011 | 0.86 | SRPK1 (0.47) | — | |
| SCHEMBL13060200 | 0.76 | ACKR3 (0.45) | CYP3A4TBK1 | |
| SCHEMBL13319049 | 0.76 | MAPK1 (0.57) | CYP3A4TBK1MAPK1NPSR1 | |
| SCHEMBL13003276 | 0.75 | ACKR3 (0.44) | CYP3A4TBK1MAPK1 | |
| SCHEMBL14095012 | 0.75 | CYP3A4 (0.47) | CYP3A4TBK1 | |
| SCHEMBL14095196 | 0.74 | ICAM1 (0.47) | TBK1 | |
| SCHEMBL13003285 | 0.74 | CYP3A4 (0.51) | CYP3A4TBK1 | |
| SCHEMBL13003274 | 0.74 | CYP3A4 (0.51) | CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008108958-A2 | BENZIMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF | SCHERING CORPORATION (US) | 2008-09-12 | — | — | WO | disclosed |
| EP-1499316-B1 | (1-4-PIPERIDINYL)BENZIMIDAZOLE DERIVATIVES USEFUL AS HISTAMINE H3 ANTAGONISTS | SCHERING CORP (US) | 2008-03-19 | — | — | EP | disclosed |