⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2402912 | 0.95 | DRD4 (0.41) | — | |
| SCHEMBL13415333 | 0.93 | DRD4 (0.40) | — | |
| SCHEMBL22604338 | 0.93 | DRD4 (0.40) | — | |
| SCHEMBL12082578 | 0.78 | GRM5 (0.41) | — | |
| SCHEMBL3516499 | 0.77 | HTR2C (0.39) | — | |
| SCHEMBL8316966 | 0.72 | MAOA (0.36) | — | |
| SCHEMBL22317590 | 0.71 | LMNA (0.41) | — | |
| SCHEMBL25120514 | 0.71 | HRH3 (0.34) | — | |
| SCHEMBL11517457 | 0.71 | HTR2C (0.34) | — | |
| SCHEMBL31696695 | 0.71 | PLK1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12479827-B2 | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2025-11-25 | — | — | US | disclosed |
| US-20240076286-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-03-07 | — | — | US | disclosed |
| US-20240002363-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-01-04 | — | — | US | disclosed |
| US-11760745-B2 | Heteroaromatic carboxamide derivatives as plasma kallikrein inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2023-09-19 | — | — | US | disclosed |
| WO-2021160718-A1 | HETEROAROMATIC CARBOXAMIDE DERIVATIVES AS PLASMA KALLIKREIN INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-08-19 | — | — | WO | disclosed |
| WO-2020156106-A1 | HETEROCYCLIC ARYL FORMAMIDES OR SALT THEREOF, PREPARATION METHOD, WEEDING COMPOSITION, AND APPLICATION | 青岛清原化合物有限公司 | 2020-08-06 | — | — | WO | disclosed |
| US-7714000-B2 | Substituted pyrrolidinones and their use as medicaments | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2010-05-11 | — | — | US | disclosed |
| US-7674936-B2 | Ortho-substituted aryl amides for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2010-03-09 | — | — | US | disclosed |
| US-7629463-B2 | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-12-08 | — | — | US | disclosed |
| US-20090181958-A1 | SUBSTITUTED NITROGEN-CONTAINING HETEROBICYCLES, THE PREPARATION THEREOF AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2009-07-16 | — | — | US | disclosed |
| US-7560564-B2 | Heterocyclic diamide invertebrate pest control agents | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-07-14 | — | — | US | disclosed |
| US-7429597-B2 | Substituted nitrogen-containing heterobicycles, the preparation thereof and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO., KG (DE) | 2008-09-30 | — | — | US | disclosed |
| US-20080132524-A1 | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests | CLARK DAVID ALAN | 2008-06-05 | — | — | US | disclosed |
| US-20080132496-A1 | CARBOXYLIC ACID AMIDES, THE PREPARATION THEREOF, AND THEIR USE AS PHARMACEUTICAL COMPOSITIONS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2008-06-05 | — | — | US | disclosed |
| US-7375232-B2 | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2008-05-20 | — | — | US | disclosed |
| US-7326791-B2 | Carboxylic acid amides, the preparation thereof, and their use as pharmaceutical compositions | BOEHRINGER INGELHEIM PHARMA GMBH & CO., KG (DE) | 2008-02-05 | — | — | US | disclosed |
| US-7288554-B2 | Ortho-substituted aryl amides for controlling invertebrate pests | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-10-30 | — | — | US | disclosed |
| US-20070249832-A1 | Ortho-substituted aryl amides for controlling invertebrate pests | FMC CORPORATION | 2007-10-25 | — | — | US | disclosed |