Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHA4 | P54764 | 3/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 1/20 | 0.39 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.36 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 5/20 | 0.35 |
| ▸ | FLT3 | P36888 | 5/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK1 | P06493 | 1/20 | 0.34 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.34 |
| ▸ | PAK4 | O96013 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13329326 | 0.96 | EPHA4 (0.45) | EPHA4HTR7CHUKDCUN1D1HASPIN | |
| SCHEMBL13329614 | 0.86 | EPHA4 (0.64) | EPHA4HTR7DCUN1D1ACHECDK2 | |
| SCHEMBL13329637 | 0.85 | EPHA4 (0.65) | EPHA4HTR7DCUN1D1ACHECDK2 | |
| SCHEMBL13329333 | 0.84 | EPHA4 (0.45) | EPHA4ACHECDK2FLT3CCNA1 | |
| SCHEMBL13329477 | 0.84 | EPHA4 (0.66) | EPHA4HTR7DCUN1D1ACHEMAPK14 | |
| SCHEMBL13360769 | 0.83 | HTR7 (0.38) | EPHA4HTR7CHUKDCUN1D1FLT3 | |
| SCHEMBL13329315 | 0.82 | EPHA4 (0.62) | EPHA4HTR7DCUN1D1ACHECDK2 | |
| SCHEMBL13329610 | 0.82 | ALDH1A1 (0.46) | EPHA4 | |
| SCHEMBL13329553 | 0.82 | HTR7 (0.36) | EPHA4HTR7CHUKDCUN1D1ACHE | |
| SCHEMBL13329511 | 0.82 | HTR7 (0.36) | EPHA4HTR7CHUKDCUN1D1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100113415-A1 | EPHA4 RTK INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS AND CANCER | MERCK SHARP & DOHME CORP | 2010-05-06 | — | — | US | disclosed |
| US-20100113415-A1 | EPHA4 RTK INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS AND CANCER | MERCK SHARP & DOHME CORP | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100113415-A1 | EPHA4 RTK INHIBITORS FOR TREATMENT OF NEUROLOGICAL AND NEURODEGENERATIVE DISORDERS AND CANCER | EPHA4, EPHA1, ERBB4 | EPHA4 1/4885HTR7 603/4885CHUK 505/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.