Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2354239 | 0.93 | EPHX2 (0.43) | EPHX2NR1H4PPARGPPARDPPARA | |
| SCHEMBL2354460 | 0.92 | EPHX2 (0.44) | EPHX2NR1H4PPARGPPARDPPARA | |
| SCHEMBL2354414 | 0.92 | EPHX2 (0.42) | EPHX2NR1H4PPARGPPARDPPARA | |
| SCHEMBL2363248 | 0.88 | CYP3A4 (0.54) | EPHX2NR1H4PPARGROCK2ROCK1 | |
| SCHEMBL3311096 | 0.87 | CYP3A4 (0.42) | EPHX2NR1H4PPARGPPARDPPARA | |
| SCHEMBL3308176 | 0.86 | CYP3A4 (0.42) | EPHX2NR1H4MAPTCYP3A4TP53 | |
| SCHEMBL3311934 | 0.85 | MAPK1 (0.43) | ROCK2ROCK1MAPTCYP3A4 | |
| SCHEMBL2364053 | 0.83 | CYP3A4 (0.49) | EPHX2NR1H4PPARGROCK2ROCK1 | |
| SCHEMBL3308708 | 0.80 | HPGD (0.51) | EPHX2MAPTCYP3A4HPGD | |
| SCHEMBL2364475 | 0.80 | CYP3A4 (0.42) | EPHX2NR1H4MAPTCYP3A4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100111900-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | ROCHE PALO ALTO LLC | 2010-05-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100111900-A1 | HETEROCYCLIC ANTIVIRAL COMPOUNDS | POLR2A, EIF2AK2, POLR2B | EPHX2 3590/4885NR1H4 928/4885PPARG 2681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.