⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL451332 | 0.74 | TRPA1 (0.30) | — | |
| SCHEMBL5622867 | 0.71 | — | — | |
| SCHEMBL8431705 | 0.64 | CYP3A4 (0.40) | — | |
| SCHEMBL151612 | 0.62 | — | — | |
| SCHEMBL1079397 | 0.62 | TRPA1 (0.42) | — | |
| SCHEMBL168345 | 0.59 | TRPA1 (0.56) | — | |
| SCHEMBL4742301 | 0.59 | TRPA1 (0.50) | — | |
| SCHEMBL15102981 | 0.59 | — | — | |
| SCHEMBL7405309 | 0.58 | — | — | |
| Thianthrene SCHEMBL7786 | 0.57 | BCHE (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 360 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3245198-B1 | PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS | NOVARTIS AG (CH) | 2020-03-11 | — | — | EP | claimed |
| US-10065943-B2 | Pyrrolidine derivatives as angiotensin II type 2 antagonists | NOVARTIS AG (CH) | 2018-09-04 | — | — | US | claimed |
| US-20170369473-A1 | PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS | SPINIFEX PHARMACEUTICALS PTY LTD (AU) | 2017-12-28 | — | — | US | claimed |
| EP-3245198-A1 | PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS | Novartis AG (CH) | 2017-11-22 | — | — | EP | claimed |
| WO-2016113668-A1 | PYRROLIDINE DERIVATIVES AS ANGIOTENSIN II TYPE 2 ANTAGONISTS | NOVARTIS AG (CH) | 2016-07-21 | — | — | WO | claimed |
| US-7288548-B2 | Spiro compounds and methods for the modulation of chemokine receptor activity | VIROCHEM PHARMA, INC. (CA) | 2007-10-30 | — | — | US | claimed |
| US-6740655-B2 | 3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 4-SPECIFIC INHIBITORS REDUCE EOSINOPHIL INFLUX TO THE LUNGS; SIDE EFFECT REDUCTION; ANTIINFLAMMATORY AGENT; ANTIALLERGENS; RESPIRATORY SYSTEM DISORDERS, ESPECIALLY ASTHMA | PFIZER INC | 2004-05-25 | — | — | US | claimed |
| US-20030144300-A1 | Pyrimidine carboxamides useful as inhibitors of pde4 isozymes | PFIZER PRODUCTS INC. | 2003-07-31 | — | — | US | claimed |
| CN-111867623-B | TOLL-like receptor ligands | 英尼穆内公司 | 2024-06-04 | — | — | CN | disclosed |
| US-20240150508-A1 | PHOTO-SWITCHABLE CHEMISTRY FOR REVERSIBLE HYDROGELS AND REUSABLE FLOW CELLS | ILLUMINA, INC. (US) | 2024-05-09 | — | — | US | disclosed |
| CN-112367982-B | Amide compounds, compositions and methods of treatment as kinase inhibitors | 转化药物开发有限责任公司 | 2024-05-07 | — | — | CN | disclosed |
| CN-114907271-B | Compositions of benzamide and active compounds and methods of use thereof | 转化药物开发有限责任公司 | 2024-05-07 | — | — | CN | disclosed |
| WO-2024081563-A1 | PHOTO-SWITCHABLE CHEMISTRY FOR REVERSIBLE HYDROGELS AND REUSABLE FLOW CELLS | ILLUMINA, INC. (US) | 2024-04-18 | — | — | WO | disclosed |
| US-20240117426-A1 | NANOGEL PARTICLES HAVING DUAL FUNCTIONALITY AND TEMPERATURE RESPONSIVENESS FOR PARTICLE CLUSTERING IN NUCLEIC ACID SEQUENCING SYSTEMS | ILLUMINA, INC. (US) | 2024-04-11 | — | — | US | disclosed |
| EP-0930299-A1 | PROPIONIC ACID DERIVATIVES AND APPLICATIONS THEREOF | Japan Tobacco Inc. (JP) | 1999-07-21 | — | — | EP | disclosed |
| US-5728720-A | HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; TREATMENT OF DIABETES | JAPAN TOBACCO INC. (JP) | 1998-03-17 | — | — | US | disclosed |
| US-5719155-A | CARDIOVASCULAR DISORDERS | JAPAN TOBACCO INC. (JP) | 1998-02-17 | — | — | US | disclosed |
| EP-0684242-A1 | ISOXAZOLIDINEDIONE DERIVATIVE AND USE THEREOF | JAPAN TOBACCO INC. (JP) | 1995-11-29 | — | — | EP | disclosed |
| EP-0677519-A1 | CHROMAN DERIVATIVE AND MEDICINAL USE THEREOF | Japan Tobacco Inc. (JP) | 1995-10-18 | — | — | EP | disclosed |
| EP-0603419-A1 | NOVEL THIAZOLIDINEDIONE COMPOUND AND USE THEREOF | Japan Tobacco Inc. (JP) | 1994-06-29 | — | — | EP | disclosed |